Sayyah Mohammad, Yousefi-Pour Mahyar, Narenjkar Jamshid
Department of Physiology and Pharmacology, Institute Pasteur of Iran, Pasteur Avenue, Tehran 13164, Iran.
Epilepsy Res. 2005 Jan;63(1):11-6. doi: 10.1016/j.eplepsyres.2004.10.001. Epub 2004 Dec 1.
Vitamin A (Vit A) and its derivatives have recently been reported to be implicated in synaptic plasticity. In this study, the possible effect of Vit A and its precursor, beta-carotene on acute seizure and kindling, induced by pentylenetetrazole (PTZ) was assessed. Vit A and beta-carotene were evaluated for their ability to: (1) elevate the threshold of clonic seizures induced by i.v. infusion of PTZ; (2) suppress the seizures (clonic and tonic) and lethality induced by i.p. PTZ in PTZ-kindled mice (anticonvulsant effect); (3) attenuate the development of sensitization to convulsive and lethal effects of i.p. PTZ in kindled mice (anti-epileptogenic effect). Diazepam was employed as positive control. All the drugs showed anti-epileptogenic effect against PTZ-induced tonic seizures and lethality. Vit A and beta-carotene had no effect on clonic seizures threshold and also on tonic seizures and lethality induced by PTZ in kindled mice. Non-genomic and genomic mechanisms could be involved in the anti-epileptogenic effect of Vit A and beta-carotene.
维生素A（Vit A）及其衍生物最近被报道与突触可塑性有关。在本研究中，评估了Vit A及其前体β-胡萝卜素对戊四氮（PTZ）诱导的急性惊厥和点燃效应的可能影响。评估了Vit A和β-胡萝卜素的以下能力：（1）提高静脉注射PTZ诱导的阵挛性惊厥阈值；（2）抑制PTZ点燃小鼠腹腔注射PTZ诱导的惊厥（阵挛性和强直性）和致死性（抗惊厥作用）；（3）减弱点燃小鼠对腹腔注射PTZ惊厥和致死效应的敏感性发展（抗癫痫发生作用）。地西泮用作阳性对照。所有药物对PTZ诱导的强直性惊厥和致死性均显示出抗癫痫发生作用。Vit A和β-胡萝卜素对阵挛性惊厥阈值以及PTZ点燃小鼠的强直性惊厥和致死性均无影响。非基因组和基因组机制可能参与了Vit A和β-胡萝卜素的抗癫痫发生作用。
