Bakhtiari Elham, Heydarian Farhad, Azmoudeh Fatemeh, Kaffashbashi Maziyar, Heidarian Mohammad
Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Heliyon. 2023 Jul 25;9(8):e18536. doi: 10.1016/j.heliyon.2023.e18536. eCollection 2023 Aug.
The role of vitamins and antioxidants in the febrile seizure (FS) has recently become of interest. The role of Vitamin A in seizure is remained controversial. It may suppress or provoke the seizure. In present study, the serum vitamin A level in febrile patients was compared with febrile seizure children for the first time.
In a cross-sectional study, eighty children aged 6-60 months including 40 febrile children and 40 children with FS were included. Blood samples were obtained, and the serum level of vitamin A and other blood parameters were measured.
Patients were similar in demographic characteristics (p = 0.06 for age and p = 0.41 for sex). The serum vitamin A level was 0.19 (0.12, 0.25) and 0.22 (0.17, 0.29) milligram per liter (mg/L) in febrile and FS group respectively (p = 0.33). In children aged less than 24 months the serum vitamin A level in FS and febrile group was 0.22 ± 0.07 and 0.24 ± 0.12 mg/L respectively (p = 0.56). In children aged more than 24 months the serum vitamin A level in FS group was higher significantly in comparison with febrile group (0.25 ± 0.11 and 0.16 ± 0.07 mg/L respectively, p = 0.01).
Serum vitamin A level was not different in febrile children with and without seizure. Surprisingly in children aged more than 24 months, the serum level of vitamin A was higher in FS group than in the febrile children. More studies are needed to confirm the present observation
维生素和抗氧化剂在热性惊厥（FS）中的作用最近受到关注。维生素A在惊厥中的作用仍存在争议。它可能抑制或引发惊厥。在本研究中，首次比较了发热患者与热性惊厥儿童的血清维生素A水平。
在一项横断面研究中，纳入了80名6至60个月大的儿童，其中包括40名发热儿童和40名热性惊厥儿童。采集血样，测量血清维生素A水平和其他血液参数。
患者在人口统计学特征方面相似（年龄p = 0.06，性别p = 0.41）。发热组和热性惊厥组的血清维生素A水平分别为0.19（0.12，0.25）和0.22（0.17，0.29）毫克/升（mg/L）（p = 0.33）。在24个月以下的儿童中，热性惊厥组和发热组的血清维生素A水平分别为0.22±0.07和0.24±0.12 mg/L（p = 0.56）。在24个月以上的儿童中，热性惊厥组的血清维生素A水平显著高于发热组（分别为0.25±0.11和0.16±0.07 mg/L，p = 0.01）。
有惊厥和无惊厥的发热儿童血清维生素A水平无差异。令人惊讶的是，在24个月以上的儿童中，热性惊厥组的血清维生素A水平高于发热儿童。需要更多研究来证实目前的观察结果。
