Alverdy John, Zaborina Olga, Wu Licheng
University of Chicago, Chicago, Illinois 60637, USA.
Curr Opin Clin Nutr Metab Care. 2005 Mar;8(2):205-9. doi: 10.1097/00075197-200503000-00016.
Most literature that examines gut barrier function focuses on alterations in bacterial flora, changes in mucosal epithelium, or the integrity of the mucosal defenses. This review examines new concepts on the interaction between bacteria and the host, the complex relationships that serve to benefit both in times of health, and the alterations and responses that occur during illness.
Recent work has demonstrated a more complex relationship between bacteria and barrier integrity and between bacteria themselves, which creates a symbiotic relationship beneficial to both host and flora. Host responses alter this balance, inducing changes in bacteria that may be deleterious to both.
With a better understanding of the bacteria-host interactions in health and the alterations induced by critical illness, new therapies that improve the environment of both may lead to better recovery rates in intensive care unit patients.
大多数研究肠道屏障功能的文献都聚焦于细菌菌群的改变、黏膜上皮的变化或黏膜防御的完整性。本综述探讨了细菌与宿主相互作用的新概念、在健康状态下对双方都有益的复杂关系，以及疾病期间发生的改变和反应。
最近的研究表明，细菌与屏障完整性之间以及细菌自身之间存在更复杂的关系，这种关系形成了一种对宿主和菌群都有益的共生关系。宿主反应会改变这种平衡，引发对双方都可能有害的细菌变化。
随着对健康状态下细菌与宿主相互作用以及危重病引发的改变有了更深入的了解，改善双方环境的新疗法可能会提高重症监护病房患者的康复率。
