Deby C, Deby-Dupont G, Bourdon-Neuray J, Simon D
C R Seances Soc Biol Fil. 1978;172(5):1017-24.
The hypotensive effect of arachidonic acid in the rabbit increases simultaneously with the fall of the plasmatic unesterified fatty acids (NEFA), after treatment with nicotinic acid or heparin. In the case of nicotinic acid sensitization, which occurs in 10 minutes, the fall of NEFA occurs immediately. The sensitization by heparin appears only after 40 minutes following the injection; during this latency, the NEFA are enhanced; after the fall of NEFA, the rabbit becomes more sensitive to arachidonic acid. Mechanisms of heparinic sensitization are discussed.
用烟酸或肝素处理后，兔体内花生四烯酸的降压作用随血浆未酯化脂肪酸（NEFA）的下降而同时增强。在10分钟内发生的烟酸致敏情况下，NEFA立即下降。肝素致敏仅在注射后40分钟出现；在此潜伏期内，NEFA升高；NEFA下降后，兔对花生四烯酸变得更敏感。文中讨论了肝素致敏的机制。
