Sica A L, Siddiqi Z A, Pisana F M
Department of Pediatrics, Schneider Children's Hospital, Albert Einstein College of Medicine, New Hyde Park, NY 11042.
Brain Res Dev Brain Res. 1992 Feb 21;65(2):281-3. doi: 10.1016/0165-3806(92)90190-8.
In developing kittens, antagonism of N-methyl-D-aspartate receptors by systemic injections of MK-801 produced: (a) blockage of the inspiratory off-switch, prolonging phrenic and hypoglossal discharges; (b) age-dependent changes of sympathetic inspiratory discharges, elimination of inspiratory-related discharges in animals less than or equal to 36 days old and prolongation of these discharges in older animals; (c) suppression of high-frequency oscillations in phrenic activities.
在发育中的小猫中，通过全身注射MK-801拮抗N-甲基-D-天冬氨酸受体产生了：(a)吸气切断开关受阻，膈神经和舌下神经放电延长；(b)交感吸气放电的年龄依赖性变化，在小于或等于36日龄的动物中消除吸气相关放电，而在年龄较大的动物中延长这些放电；(c)抑制膈神经活动中的高频振荡。
