Hulme Katina D, Gallo Linda A, Short Kirsty R
School of Biomedical Sciences, The University of Queensland, BrisbaneQLD, Australia.
Mater Research Institute, The University of Queensland, BrisbaneQLD, Australia.
Front Microbiol. 2017 May 22;8:861. doi: 10.3389/fmicb.2017.00861. eCollection 2017.
Following the 2009 H1N1 influenza virus pandemic, numerous studies identified the striking link between diabetes mellitus and influenza disease severity. Typically, influenza virus is a self-limiting infection but in individuals who have a pre-existing chronic illness, such as diabetes mellitus, severe influenza can develop. Here, we discuss the latest clinical and experimental evidence for the role of diabetes in predisposing the host to severe influenza. We explore the possible mechanisms that underlie this synergy and highlight the, as yet, unexplored role that blood glucose oscillations may play in disease development. Diabetes is one of the world's fastest growing chronic diseases and influenza virus represents a constant and pervasive threat to human health. It is therefore imperative that we understand how diabetes increases influenza severity in order to mitigate the burden of future influenza epidemics and pandemics.
2009年甲型H1N1流感病毒大流行之后，众多研究确定了糖尿病与流感疾病严重程度之间的显著关联。通常，流感病毒感染是自限性的，但在患有诸如糖尿病等既有慢性疾病的个体中，可能会发展为严重流感。在此，我们讨论糖尿病使宿主易患严重流感这一作用的最新临床和实验证据。我们探究这种协同作用背后的可能机制，并强调血糖波动在疾病发展中可能发挥的、尚未被探索的作用。糖尿病是全球增长最快的慢性疾病之一，流感病毒对人类健康构成持续且普遍的威胁。因此，我们必须了解糖尿病如何增加流感的严重程度，以便减轻未来流感流行和大流行的负担。
