Kölsch H, Jessen F, Freymann N, Kreis M, Hentschel F, Maier W, Heun R
Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.
Neurosci Lett. 2005 Mar 22;377(1):37-9. doi: 10.1016/j.neulet.2004.11.062. Epub 2004 Dec 10.
Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an association of the I-allele with the risk of AD. A few small studies also investigated the effect of ACE polymorphism on the risk of vascular dementia (VD). We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. We found the I/I genotype to be associated with an increased risk of AD, but not with the risk of VD. Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD.
不同的研究探讨了血管紧张素转换酶（ACE）插入/缺失（I/D）多态性对阿尔茨海默病（AD）风险的影响。然而，关于ACE-I等位基因与AD关联的结果尚无定论。最近的一项荟萃分析报告了I等位基因与AD风险之间的关联。一些小型研究也探讨了ACE多态性对血管性痴呆（VD）风险的影响。我们研究了351例AD患者、155例VD患者和348例健康对照者中ACE I/D多态性的影响。我们发现I/I基因型与AD风险增加相关，但与VD风险无关。提示ACE多态性存在细胞特异性效应，对神经元细胞的进一步研究可能有助于理解这种多态性在AD中的作用。
