Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, 1449614525, Iran.
School of Pharmacy, Azad University of Medical Sciences, Tehran, Iran.
Biochem Genet. 2021 Feb;59(1):31-41. doi: 10.1007/s10528-020-09986-7. Epub 2020 Jul 27.
Deregulation of the renin-angiotensin system (RAS) plays an important role in suicide. Angiotensin converting enzyme (ACE) gene is a key component in this system. The relationship between insertion/deletion (I/D) polymorphism of ACE gene with suicide attempt (SA) is controversial. According to previous studies, allele D in this polymorphism has been considered as a potential risk factor for suicide. However, no study has been conducted in Iran to investigate this matter. This case-control study has focused on investigating the association of ACE I/D polymorphism (rs1799752) with SA in an Iranian population. The frequency of genotypes was 14% for II, 55% for ID, and 31% for DD in the case group (100 persons), and 18% for II, 74% for ID, and 8% for DD in control group (100 persons). Results show there was a significant difference in the distribution of ACE I/D polymorphism genotypes in men with SA compared to controls, as well as in women with SA compared to controls. Also, there was a significant association between DD genotype and the risk of SA compared to II genotype as reference. The severity of depression was significantly different between DD and II genotypes in SA group. According to the results, we suggest that the presence of DD genotype is possibly associated with an increased risk of SA. Maybe part of that is related to severity of depression in DD genotypes carriers of ACE I/D polymorphism.
肾素-血管紧张素系统 (RAS) 的失调在自杀中起着重要作用。血管紧张素转换酶 (ACE) 基因是该系统的关键组成部分。ACE 基因插入/缺失 (I/D) 多态性与自杀未遂 (SA) 之间的关系存在争议。根据以往的研究，该多态性中的等位基因 D 被认为是自杀的潜在危险因素。然而，伊朗尚未对此进行研究。本病例对照研究旨在调查 ACE I/D 多态性 (rs1799752) 与伊朗人群中 SA 的关系。在病例组（100 人）中，基因型频率为 II 型占 14%，ID 型占 55%，DD 型占 31%，在对照组（100 人）中，基因型频率为 II 型占 18%，ID 型占 74%，DD 型占 8%。结果表明，SA 男性与对照组相比，ACE I/D 多态性基因型分布存在显著差异，SA 女性与对照组相比也存在显著差异。此外，与 II 基因型作为参考相比，DD 基因型与 SA 的风险显著相关。在 SA 组中，DD 基因型和 II 基因型之间的抑郁严重程度存在显著差异。根据结果，我们建议 DD 基因型的存在可能与 SA 风险增加有关。也许部分原因与 ACE I/D 多态性携带者的 DD 基因型中抑郁的严重程度有关。
