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[睡眠与单胺类物质:系统注射氚标记的5-羟色氨酸(5-HTP³H)或二羟基苯丙氨酸(DOPA³H)后中枢神经元的差异放射自显影术]

[Sleep and monoamines: differential radioautography of central neurons after systematic injection of tritiated 5-hydroxytryptophane (5 HTP 3H) or of dihydroxyphenylalanine (DOPA 3H)].

作者信息

Petitjean F, Buda C, Janin M, Touret M, Salvert D, Jouvet M, Bobillier P

出版信息

C R Acad Hebd Seances Acad Sci D. 1978 Nov 6;287(12):1135-9.

PMID:157232
Abstract

In normal cats 90 min. after the intravenous injection of 5 mg/kg of 5 HTP and 3H 5 HTP or DOPA and 3H DOPA a few reactive nerve cell bodies were identified by radioautography. On the contrary, 48 hrs. after p-chlorophenylalanin or subtotal lesion of raphe nuclei, these tracers showed numerous reactive neurons inside or outside the central monoaminergic systems.

摘要

在正常猫静脉注射5毫克/千克的5-羟色氨酸和3H-5-羟色氨酸或多巴和3H-多巴90分钟后,通过放射自显影鉴定出一些反应性神经细胞体。相反,在对氯苯丙氨酸处理或中缝核次全损伤48小时后,这些示踪剂在中枢单胺能系统内外显示出大量反应性神经元。

相似文献

1
[Sleep and monoamines: differential radioautography of central neurons after systematic injection of tritiated 5-hydroxytryptophane (5 HTP 3H) or of dihydroxyphenylalanine (DOPA 3H)].[睡眠与单胺类物质:系统注射氚标记的5-羟色氨酸(5-HTP³H)或二羟基苯丙氨酸(DOPA³H)后中枢神经元的差异放射自显影术]
C R Acad Hebd Seances Acad Sci D. 1978 Nov 6;287(12):1135-9.
2
[Selective identification of indoleamine-containing neurons under particular pharmacological (PCPA, 5-HTP) and behavioral situations (sleep) (author's transl)].
J Physiol (Paris). 1981;77(2-3):237-9.
3
L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan share the same transporter in Opossum kidney cells.L-3,4-二羟基苯丙氨酸和L-5-羟色氨酸在负鼠肾细胞中共享同一转运体。
Int J Biochem Cell Biol. 1998 Feb;30(2):243-50. doi: 10.1016/s1357-2725(97)00115-5.
4
The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study.5-羟色氨酸(5-HTP)在对氯苯丙氨酸(p-CPA)预处理大鼠睡眠/觉醒周期调节中的作用:一项多方法研究
Exp Brain Res. 1991;86(1):117-24. doi: 10.1007/BF00231046.
5
[Effect of cooling and electrical stimulation of nuclei of raphe system on states of alertness in cat].[中缝系统核团的冷却和电刺激对猫警觉状态的影响]
Electroencephalogr Clin Neurophysiol. 1979 Sep;47(3):289-308. doi: 10.1016/0013-4694(79)90281-5.
6
Autoradiographic studies on distribution of L-3,4-dihydroxyphenylalanine (L-DOPA)-14C and L-5-hydroxytryptophan (L-5-HTP)-14C in the cat brain.猫脑中L-3,4-二羟基苯丙氨酸(L-DOPA)-14C和L-5-羟色氨酸(L-5-HTP)-14C分布的放射自显影研究。
Jpn J Pharmacol. 1980 Dec;30(6):795-805. doi: 10.1254/jjp.30.795.
7
[Insomnia induced by P-chlorophenylalanine in cats. Its reversibility by intraventricular injections of indolamines].[对氯苯丙氨酸诱导猫失眠。脑室内注射吲哚胺可逆转这种失眠]
C R Seances Acad Sci D. 1980 Dec 15;291(13):1063-6.
8
[Implication of hypothalamic structures in indolaminergic mechanisms of paradoxical sleep].[下丘脑结构在异相睡眠吲哚胺能机制中的作用]
C R Seances Acad Sci III. 1983;297(11):531-4.
9
Changes in the effects of hexobarbital in male rats induced by manipulations of monoamines through reserpine or pargyline combined with Dopa or 5-hydroxytryptophane.通过利血平或优降宁联合多巴或5-羟色氨酸对单胺进行处理所诱导的雄性大鼠中己巴比妥作用的变化。
Acta Pharmacol Toxicol (Copenh). 1971;30(5):353-65. doi: 10.1111/j.1600-0773.1972.tb00667.x.
10
Metabolism of L-DOPA and 5-HTP in the exocrine pancreas studied with autoradiography in the electron microscope.利用电子显微镜放射自显影技术研究外分泌胰腺中左旋多巴和5-羟色氨酸的代谢。
J Ultrastruct Res. 1972 Feb;38(3):265-78. doi: 10.1016/s0022-5320(72)90004-4.

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Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence.调节哺乳动物睡眠-觉醒行为的神经生物学机制:对历史证据的重新解读以及当代细胞和分子证据的纳入
Neurosci Biobehav Rev. 2007;31(5):775-824. doi: 10.1016/j.neubiorev.2007.02.004. Epub 2007 Mar 12.