Petitjean F, Buda C, Janin M, Sallanon M, Jouvet M
C R Seances Acad Sci D. 1980 Dec 15;291(13):1063-6.
Intraventricular injection of 250 microgram of 5 HTP induces both slow wave and paradoxical sleep, after 20-60 min. latencies, in insomniac Cats pretreated with P-chlorophenylalanine. Direct injections of 5 HTP in several brain stem structures do not induce sleep. The long latency or paradoxical sleep induction and its suppression with chloramphenicol suggest that indolamines are not directly responsible for paradoxical sleep, but that they act by controlling the synthesis and/or the liberation in the periventricular system of some specific paradoxical sleep inducing factor.
在经对氯苯丙氨酸预处理的失眠猫中，脑室内注射250微克5-羟色氨酸，20 - 60分钟潜伏期后可诱导慢波睡眠和异相睡眠。直接在几个脑干结构中注射5-羟色氨酸不会诱导睡眠。异相睡眠诱导的长潜伏期及其被氯霉素抑制表明，吲哚胺并非直接导致异相睡眠，而是通过控制某些特定异相睡眠诱导因子在脑室周系统中的合成和/或释放来发挥作用。
