Kotsis Vasilios, Stabouli Stella, Bouldin Marshall, Low Annette, Toumanidis Savvas, Zakopoulos Nikos
Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodestrial University, Athens, Greece.
Hypertension. 2005 Apr;45(4):602-7. doi: 10.1161/01.HYP.0000158261.86674.8e. Epub 2005 Feb 21.
The purpose of the present study was to determine the relationship between body mass index (BMI) and parameters derived from 24-hour ambulatory blood pressure monitoring including mean 24-hour daytime and nighttime systolic and diastolic blood pressures, 24-hour daytime and nighttime pulse pressure, mean 24-hour daytime and nighttime heart rate, dipping and nondipping status. 3216 outpatient subjects who visited our hypertension center and were never treated with antihypertensive medication underwent 24-hour blood pressure monitoring. BMI was significantly correlated with clinic systolic and diastolic blood pressures. Significant correlations were also found between BMI and mean 24-hour daytime and nighttime systolic blood pressure, 24-hour daytime and nighttime pulse pressure, and mean 24-hour daytime and nighttime heart rate. In multivariate regression analysis, clinic systolic, diastolic blood pressure, mean 24-hour systolic blood pressure, 24-hour pulse pressure, and high-density lipoprotein were independently correlated with BMI. The incidence of white coat hypertension was higher in overweight and obese patients than in normal weight subjects. Confirmed ambulatory blood pressure hypertension was also found to be higher in overweight and obese individuals compared with normal weight subjects. Our data also highlight the higher incidence of nondipping status in obesity. These findings suggest that obese patients had increased ambulatory blood pressure parameters and altered circadian blood pressure rhythm with increased prevalence of nondipping status.
本研究的目的是确定体重指数（BMI）与24小时动态血压监测得出的参数之间的关系，这些参数包括24小时日间和夜间的平均收缩压和舒张压、24小时日间和夜间脉压、24小时日间和夜间平均心率、血压波动状态。3216名前来我们高血压中心就诊且从未接受过抗高血压药物治疗的门诊患者接受了24小时血压监测。BMI与诊室收缩压和舒张压显著相关。在BMI与24小时日间和夜间平均收缩压、24小时日间和夜间脉压以及24小时日间和夜间平均心率之间也发现了显著相关性。在多变量回归分析中，诊室收缩压、舒张压、24小时平均收缩压、24小时脉压和高密度脂蛋白与BMI独立相关。超重和肥胖患者的白大衣高血压发病率高于正常体重受试者。与正常体重受试者相比，超重和肥胖个体的确诊动态血压高血压也更高。我们的数据还突出了肥胖患者中血压波动状态发生率较高的情况。这些发现表明，肥胖患者的动态血压参数增加，昼夜血压节律改变，血压波动状态的患病率增加。
