Department of Cardiology, Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Center, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, China.
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
BMC Pediatr. 2024 May 22;24(1):353. doi: 10.1186/s12887-024-04804-0.
For adolescents, abnormal dipping patterns in blood pressure (BP) are associated with early-onset organ damage and a higher risk of cardiovascular disorders in adulthood. Obesity is one of the most common reasons for abnormal BP dipping in young people. However, it is unknown whether the severity of obesity is associated with BP dipping status and whether this association is sex-dependent.
499 participants between 12 and 17 years old with overweight or obesity underwent ambulatory blood pressure monitoring (ABPM) between April 2018 and January 2019 in Beijing and Baoding. Participants were grouped by body mass index (BMI) into overweight (BMI 85th-95th percentile), obese (BMI ≥ 95th percentile) and severely obese (BMI ≥ 120% of 95th percentile or ≥ 35 kg/m) groups. Non-dipping was defined as a < 10% reduction in BP from day to night. The interaction effect between sex and obesity degree was also analyzed.
326 boys and 173 girls were included, of whom 130 were overweight, 189 were obese, and 180 were severely obese. Girls with severe obesity had a higher prevalence of non-dipping, but boys showed no significant differences in BP dipping status between obesity categories. In addition, as obesity severity went up, a more evident increase in night-time SBP was observed in girls than in boys.
Severely obese is associated with a higher prevalence of non-BP dipping patterns in girls than in boys, which suggests that the relationship between the severity of obesity and BP dipping status might be sex-specific.
对于青少年来说，血压（BP）的异常下降模式与早期器官损伤和成年后心血管疾病风险增加有关。肥胖是年轻人 BP 下降异常的最常见原因之一。然而，肥胖的严重程度是否与 BP 下降状态有关，以及这种关联是否存在性别依赖性尚不清楚。
2018 年 4 月至 2019 年 1 月，北京和保定的 499 名 12 至 17 岁超重或肥胖的参与者接受了动态血压监测（ABPM）。根据体重指数（BMI），参与者被分为超重（BMI 第 85-95 百分位）、肥胖（BMI≥第 95 百分位）和重度肥胖（BMI≥第 95 百分位的 120%或≥35kg/m）组。非杓型定义为夜间血压下降幅度<10%。还分析了性别和肥胖程度之间的交互作用效应。
共纳入 326 名男孩和 173 名女孩，其中 130 名超重，189 名肥胖，180 名重度肥胖。重度肥胖女孩非杓型的发生率较高，但肥胖程度不同的男孩之间 BP 下降状态无显著差异。此外，随着肥胖程度的加重，女孩夜间 SBP 的升高更为明显，而男孩则没有。
与男孩相比，严重肥胖的女孩非杓型的发生率更高，这表明肥胖严重程度与 BP 下降状态之间的关系可能具有性别特异性。
