de Brevern Alexandre G, Benros Cristina, Gautier Romain, Valadié Héléne, Hazout Serge, Etchebest Catherine
Equipe de Bioinformatique Génomique et Moléculaire, INSERM E03-46, Université Denis Diderot - Paris 7, 75251 Paris, France.
In Silico Biol. 2004;4(3):381-6.
A statistical analysis of the PDB structures has led us to define a new set of small 3D structural prototypes called Protein Blocks (PBs). This structural alphabet includes 16 PBs, each one is defined by the (phi, psi) dihedral angles of 5 consecutive residues. The amino acid distributions observed in sequence windows encompassing these PBs are used to predict by a Bayesian approach the local 3D structure of proteins from the sole knowledge of their sequences. LocPred is a software which allows the users to submit a protein sequence and performs a prediction in terms of PBs. The prediction results are given both textually and graphically.
对蛋白质数据银行（PDB）结构的统计分析使我们定义了一组新的小型3D结构原型，称为蛋白质块（PBs）。这个结构字母表包括16个PBs，每个PBs由5个连续残基的（φ，ψ）二面角定义。在包含这些PBs的序列窗口中观察到的氨基酸分布用于通过贝叶斯方法仅根据蛋白质序列来预测其局部3D结构。LocPred是一款软件，允许用户提交蛋白质序列并根据PBs进行预测。预测结果以文本和图形形式给出。
