Bender Judith
Department of Biochemistry and Molecular Biology, Johns Hopkins University, Bloomberg School of Public Health , 615 N. Wolfe St., Baltimore, Maryland 21205, USA.
Annu Rev Plant Biol. 2004;55:41-68. doi: 10.1146/annurev.arplant.55.031903.141641.
In many eukaryotes, including plants, DNA methylation provides a heritable mark that guides formation of transcriptionally silent heterochromatin. In plants, aberrant RNA signals direct DNA methylation to target sequences, sometimes appropriately and sometimes inappropriately. This chapter discusses the generation of RNA signals for epigenetic changes, the factors that mediate those changes, and some of the consequences of those changes for plant gene expression and genome integrity.
在包括植物在内的许多真核生物中,DNA甲基化提供了一种可遗传的标记,用于指导转录沉默异染色质的形成。在植物中,异常的RNA信号将DNA甲基化导向靶序列,有时是合适的,有时是不合适的。本章讨论了用于表观遗传变化的RNA信号的产生、介导这些变化的因素,以及这些变化对植物基因表达和基因组完整性的一些影响。