Todd Matthew H
Department of Chemistry, Queen Mary, University of London, Mile End Road, London, UKE1 4NS.
Chem Soc Rev. 2005 Mar;34(3):247-66. doi: 10.1039/b104620a. Epub 2005 Feb 8.
It is tempting for those in the field of organic synthesis to liken the process of retrosynthesis to a game of chess. That the world chess champion was recently defeated by a computer leads us to think that perhaps new and powerful computing methods could be applied to synthetic problems. Here the analogy between synthesis and chess is outlined. Achievements in the 35-year history of computer-aided synthetic design are described, followed by some more recent developments.
有机合成领域的人们很容易将逆合成过程比作一场国际象棋游戏。国际象棋冠军最近被一台计算机击败，这让我们想到，或许可以将新的强大计算方法应用于合成问题。本文概述了合成与国际象棋之间的类比。描述了计算机辅助合成设计35年历史中的成就，随后介绍了一些最新进展。
