Mavandadi Farah, Pilotti Ake
Biotage LLC, Charlottesville, VA 22911, USA.
Drug Discov Today. 2006 Feb;11(3-4):165-74. doi: 10.1016/S1359-6446(05)03695-0.
Microwave-assisted organic synthesis has revolutionized organic synthesis. Small molecules can be built in a fraction of the time required by classical thermal methods. As a result, this technique has rapidly gained acceptance as a valuable tool for accelerating drug discovery and development processes. This article outlines the basic principles behind microwave technology and summarizes recent trends and areas in drug discovery where this technology has made an impact.
微波辅助有机合成彻底改变了有机合成。小分子可以在传统热方法所需时间的一小部分内构建出来。因此，这项技术作为加速药物发现和开发过程的宝贵工具迅速得到认可。本文概述了微波技术背后的基本原理，并总结了该技术在药物发现中产生影响的最新趋势和领域。
