镰状细胞血管阻塞危机会诱导循环血清热休克蛋白-70的释放。
Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70.
作者信息
Adewoye Adeboye H, Klings Elizabeth S, Farber Harrison W, Palaima Elizabeth, Bausero Maria A, McMahon Lillian, Odhiambo Adam, Surinder Safaya, Yoder Mark, Steinberg Martin H, Asea Alexzander
机构信息
Center for Excellence in Sickle Cell Disease, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
出版信息
Am J Hematol. 2005 Mar;78(3):240-2. doi: 10.1002/ajh.20292.
Abstract
Inflammation may play an important role in the pathophysiology of sickle cell disease (SCD), and recent studies have identified the 70-kDa heat shock protein (Hsp70) as an important mediator of inflammatory responses. Here we demonstrate a significant increase in circulating serum Hsp70 level in SCD during vaso-occlusive crisis (VOC) as compared with baseline steady-state levels (P <0.05) and a significant increase in Hsp70 levels in SCD at baseline compared with normal controls (P <0.05). Taken together, these results indicate that circulating serum Hsp70 might be a marker for VOC in SCD.
摘要
炎症可能在镰状细胞病（SCD）的病理生理学中起重要作用，最近的研究已确定70 kDa热休克蛋白（Hsp70）是炎症反应的重要介质。在此我们证明，与基线稳态水平相比，SCD患者在血管闭塞性危机（VOC）期间循环血清Hsp70水平显著升高（P <0.05），并且与正常对照相比，SCD患者基线时Hsp70水平显著升高（P <0.05）。综上所述，这些结果表明循环血清Hsp70可能是SCD中VOC的一个标志物。
相似文献
1
Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70.镰状细胞血管阻塞危机会诱导循环血清热休克蛋白-70的释放。
Am J Hematol. 2005 Mar;78(3):240-2. doi: 10.1002/ajh.20292.
2
Cytokine profile of sickle cell disease in Oman.阿曼镰状细胞病的细胞因子谱
Am J Hematol. 2004 Dec;77(4):323-8. doi: 10.1002/ajh.20196.
3
Dynamics of von Willebrand factor reactivity in sickle cell disease during vaso-occlusive crisis and steady state.血管阻塞危象和稳定状态下镰状细胞病中血管性血友病因子反应性的动力学
J Thromb Haemost. 2017 Jul;15(7):1392-1402. doi: 10.1111/jth.13728. Epub 2017 Jun 5.
4
Plasma PTX3 levels in sickle cell disease patients, during vaso occlusion and acute chest syndrome (data from Saudi population).镰状细胞病患者在血管闭塞和急性胸部综合征期间的血浆PTX3水平（来自沙特人群的数据）
Hematology. 2014 Jan;19(1):52-9. doi: 10.1179/1607845413Y.0000000092. Epub 2013 Nov 25.
5
Sickle cell vaso-occlusive crisis is associated with abnormalities in the ratio of vasoconstrictor to vasodilator prostanoids.镰状细胞血管阻塞性危机与血管收缩性前列腺素和血管舒张性前列腺素的比例异常有关。
Pediatr Res. 1995 Jul;38(1):95-102. doi: 10.1203/00006450-199507000-00017.
6
Reduction in serum IL-10 levels is a surrogate marker for predicting vaso-occlusive crisis in sickle cell disease.血清白细胞介素-10水平降低是预测镰状细胞病血管闭塞性危象的替代标志物。
Am J Hematol. 2014 Jul;89(7):789-90. doi: 10.1002/ajh.23736. Epub 2014 Apr 26.
7
Altered levels of pro-inflammatory cytokines in sickle cell disease patients during vaso-occlusive crises and the steady state condition.镰状细胞病患者血管阻塞危象和稳定状态时促炎细胞因子水平的改变。
Eur Cytokine Netw. 2013 Mar;24(1):45-52. doi: 10.1684/ecn.2013.0328.
8
Markers of endothelial dysfunction and leucocyte activation in Saudi and non-Saudi haplotypes of sickle cell disease.沙特和非沙特镰状细胞病单倍型中内皮功能障碍和白细胞活化的标志物
Ann Hematol. 2017 Jan;96(1):141-146. doi: 10.1007/s00277-016-2823-7. Epub 2016 Sep 30.
9
Plasma histamine elevation in a large cohort of sickle cell disease patients.一大群镰状细胞病患者的血浆组胺升高。
Br J Haematol. 2019 Jul;186(1):125-129. doi: 10.1111/bjh.15900. Epub 2019 Mar 28.
10
Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome.镰状细胞病伴血管闭塞性危机和急性胸部综合征患者精氨酸和一氧化氮的模式
J Pediatr Hematol Oncol. 2000 Nov-Dec;22(6):515-20. doi: 10.1097/00043426-200011000-00009.
引用本文的文献
1
Inflammatory status in pediatric sickle cell disease: Unravelling the role of immune cell subsets.小儿镰状细胞病的炎症状态：揭示免疫细胞亚群的作用。
Front Mol Biosci. 2023 Jan 10;9:1075686. doi: 10.3389/fmolb.2022.1075686. eCollection 2022.
2
Association between haematological values and heat shock protein 70 of sickle cell disease patients in Ado-Ekiti, Ekiti State, Nigeria.尼日利亚埃基提州阿多-埃基蒂镰状细胞病患者血液学值与热休克蛋白 70 的关系。
Pan Afr Med J. 2022 Sep 29;43:47. doi: 10.11604/pamj.2022.43.47.33346. eCollection 2022.
3
Longitudinal assessment of adhesion to vascular cell adhesion molecule-1 at steady state and during vaso-occlusive crises in sickle cell disease.在镰状细胞病稳态和血管闭塞性危象期间对血管细胞黏附分子-1的黏附的纵向评估。
Br J Haematol. 2022 Feb;196(4):1052-1058. doi: 10.1111/bjh.17954. Epub 2021 Dec 1.
4
The Role of RBC Oxidative Stress in Sickle Cell Disease: From the Molecular Basis to Pathologic Implications.红细胞氧化应激在镰状细胞病中的作用：从分子基础到病理意义
Antioxidants (Basel). 2021 Oct 13;10(10):1608. doi: 10.3390/antiox10101608.
5
The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance.热休克蛋白 70 伴侣系统：在红细胞形成和维持中的不同作用。
Haematologica. 2021 Jun 1;106(6):1519-1534. doi: 10.3324/haematol.2019.233056.
6
Inflammation in sickle cell disease.镰状细胞病中的炎症
Clin Hemorheol Microcirc. 2018;68(2-3):263-299. doi: 10.3233/CH-189012.
7
Red cell DAMPs and inflammation.红细胞 DAMPs 与炎症。
Inflamm Res. 2016 Sep;65(9):665-78. doi: 10.1007/s00011-016-0955-9. Epub 2016 Jun 1.
8
Pediatric Sepsis - Part V: Extracellular Heat Shock Proteins: Alarmins for the Host Immune System.小儿脓毒症 - 第五部分：细胞外热休克蛋白：宿主免疫系统的警报素
Open Inflamm J. 2011 Oct 7;4:49-60. doi: 10.2174/1875041901104010049.
9
Heat shock protein 72 expressing stress in sepsis: unbridgeable gap between animal and human studies--a hypothetical "comparative" study.脓毒症中表达热休克蛋白72的应激：动物研究与人体研究之间无法弥合的差距——一项假设性“比较”研究
Biomed Res Int. 2014;2014:101023. doi: 10.1155/2014/101023. Epub 2014 Jan 12.
10
Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation.射频消融后可检测到血清热休克蛋白 70 水平升高。
Cell Stress Chaperones. 2011 Sep;16(5):495-504. doi: 10.1007/s12192-011-0261-y. Epub 2011 Mar 26.
本文引用的文献
1
Hypoxia-induced acute lung injury in murine models of sickle cell disease.镰状细胞病小鼠模型中缺氧诱导的急性肺损伤
Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L705-14. doi: 10.1152/ajplung.00288.2002. Epub 2003 Sep 12.
2
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.细胞外HSP70利用的新型信号转导途径：Toll样受体（TLR）2和TLR4的作用
J Biol Chem. 2002 Apr 26;277(17):15028-34. doi: 10.1074/jbc.M200497200. Epub 2002 Feb 8.
3
Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease.自由基在镰状细胞病急性胸综合征发病机制中的作用
Respir Res. 2001;2(5):280-5. doi: 10.1186/rr70. Epub 2001 Jul 13.
4
Reperfusion injury pathophysiology in sickle transgenic mice.镰状转基因小鼠的再灌注损伤病理生理学
Blood. 2000 Jul 1;96(1):314-20.
5
HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine.热休克蛋白70（HSP70）通过一种依赖于CD14的途径刺激细胞因子的产生，这表明了它作为伴侣蛋白和细胞因子的双重作用。
Nat Med. 2000 Apr;6(4):435-42. doi: 10.1038/74697.
6
Endothelial cell nitric oxide production in acute chest syndrome.急性胸部综合征中内皮细胞一氧化氮的产生
Am J Physiol. 1999 Oct;277(4):H1579-92. doi: 10.1152/ajpheart.1999.277.4.H1579.
7
Pain in sickle cell disease. Rates and risk factors.镰状细胞病中的疼痛。发生率及危险因素。
N Engl J Med. 1991 Jul 4;325(1):11-6. doi: 10.1056/NEJM199107043250103.
Zotero 插件