Adewoye Adeboye H, Klings Elizabeth S, Farber Harrison W, Palaima Elizabeth, Bausero Maria A, McMahon Lillian, Odhiambo Adam, Surinder Safaya, Yoder Mark, Steinberg Martin H, Asea Alexzander
Center for Excellence in Sickle Cell Disease, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Am J Hematol. 2005 Mar;78(3):240-2. doi: 10.1002/ajh.20292.
Inflammation may play an important role in the pathophysiology of sickle cell disease (SCD), and recent studies have identified the 70-kDa heat shock protein (Hsp70) as an important mediator of inflammatory responses. Here we demonstrate a significant increase in circulating serum Hsp70 level in SCD during vaso-occlusive crisis (VOC) as compared with baseline steady-state levels (P <0.05) and a significant increase in Hsp70 levels in SCD at baseline compared with normal controls (P <0.05). Taken together, these results indicate that circulating serum Hsp70 might be a marker for VOC in SCD.
炎症可能在镰状细胞病（SCD）的病理生理学中起重要作用，最近的研究已确定70 kDa热休克蛋白（Hsp70）是炎症反应的重要介质。在此我们证明，与基线稳态水平相比，SCD患者在血管闭塞性危机（VOC）期间循环血清Hsp70水平显著升高（P <0.05），并且与正常对照相比，SCD患者基线时Hsp70水平显著升高（P <0.05）。综上所述，这些结果表明循环血清Hsp70可能是SCD中VOC的一个标志物。
