碘/钯方法在多杂环化合物合成中的应用。
Iodine/palladium approaches to the synthesis of polyheterocyclic compounds.
机构信息
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
出版信息
J Org Chem. 2010 Mar 5;75(5):1652-8. doi: 10.1021/jo902639f.
Abstract
A simple, straightforward strategy for the synthesis of polyheterocyclic compounds (PHCs) is reported, which involves iterative cycles of palladium-catalyzed Sonogashira coupling, followed by iodocyclization using I(2) or ICl. A variety of heterocyclic units, including benzofurans, benzothiophenes, indoles, and isocoumarins, can be efficiently incorporated under mild reaction conditions. In addition, variations of this strategy afford a variety of linked and fused PHCs.
摘要
报道了一种简单直接的多杂环化合物（PHC）合成策略，该策略涉及钯催化的 Sonogashira 偶联的迭代循环，然后使用 I(2) 或 ICl 进行碘环化。在温和的反应条件下，可以有效地引入各种杂环单元，包括苯并呋喃、苯并噻吩、吲哚和异香豆素。此外，该策略的变化还提供了各种连接和融合的 PHC。
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