Gitanjali B, Adithan C, Raveendran R, Shashindran C H, Chandrasekar S
Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Int J Clin Pharmacol Ther Toxicol. 1992 Apr;30(4):113-6.
Digoxin pharmacokinetics was studied in eight patients with uncomplicated type II diabetes mellitus and seven healthy volunteers. After a single oral dose of digoxin (1 mg), the drug concentration was measured in the serum collected at different time intervals, using a radioimmunoassay method. The diabetics had a higher serum concentration of drug when compared to control. The clearance rate of digoxin was significantly reduced in diabetics when compared to healthy volunteers. The elimination half-life of about 22 hours in both groups is much less than that reported in Western data. Possible reasons for this discrepancy are discussed.
对8例非复杂性II型糖尿病患者和7名健康志愿者进行了地高辛药代动力学研究。单次口服地高辛（1毫克）后，采用放射免疫分析法在不同时间间隔采集的血清中测量药物浓度。与对照组相比，糖尿病患者血清中的药物浓度更高。与健康志愿者相比，糖尿病患者地高辛的清除率显著降低。两组的消除半衰期约为22小时，远低于西方数据报道的数值。文中讨论了造成这种差异的可能原因。
