Adithan C, Sriram G, Swaminathan R P, Shashindran C H, Bapna J S, Krishnan M, Chandrasekar S
Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India.
Int J Clin Pharmacol Ther Toxicol. 1989 Oct;27(10):493-8.
Ampicillin elimination was studied in 10 poorly controlled, 6 well controlled type I and 14 poorly controlled type II diabetic patients. Two groups of age-matched healthy volunteers served as controls. After oral administration of ampicillin (500 mg), the poorly controlled type I diabetics had significantly lower serum concentration of the drug when compared to their corresponding healthy controls. The elimination half-life (t1/2) remained unaltered. Their creatinine clearance rate and urinary excretion of the drug were significantly reduced. There was no difference in these parameters between well controlled diabetics and healthy volunteers. The bioavailability data calculated from the urinary recovery of the drug, after oral and i.v. administration, suggested reduced oral absorption in poorly controlled type I diabetic patients. Ampicillin kinetics data of poorly controlled type II diabetic patients were not significantly different from that of the control group. Serum ampicillin levels and urinary excretion of the drug were similar in these groups. It is concluded that serum ampicillin level may be lower in poorly controlled type I diabetics which may be due to reduced absorption of the orally administered drug.
对10名控制不佳的I型糖尿病患者、6名控制良好的I型糖尿病患者以及14名控制不佳的II型糖尿病患者的氨苄西林消除情况进行了研究。两组年龄匹配的健康志愿者作为对照。口服氨苄西林（500毫克）后，与相应的健康对照相比，控制不佳的I型糖尿病患者的药物血清浓度显著降低。消除半衰期（t1/2）保持不变。他们的肌酐清除率和药物尿排泄量显著降低。控制良好的糖尿病患者与健康志愿者在这些参数上没有差异。根据口服和静脉注射给药后药物的尿回收率计算的生物利用度数据表明，控制不佳的I型糖尿病患者口服吸收减少。控制不佳的II型糖尿病患者的氨苄西林动力学数据与对照组无显著差异。这些组中的血清氨苄西林水平和药物尿排泄量相似。得出的结论是，控制不佳的I型糖尿病患者的血清氨苄西林水平可能较低，这可能是由于口服药物吸收减少所致。
