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左侧楔前叶对无先兆偏头痛患者情绪记忆的作用。

The contribution of the left precuneus to emotion memory in migraine without aura patients.

作者信息

Li Meiqin, Li Xiaoshu, Zhu Wanqiu, Zhu Jiajia, Wang Haibao, Gao Ziwen, Wu Xingqi, Zhou Shanshan, Wang Kai, Yu Yongqiang

机构信息

The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

The First Affiliated Hospital of Anhui Medical University, Hefei, China.

出版信息

Front Neurosci. 2022 Oct 18;16:905942. doi: 10.3389/fnins.2022.905942. eCollection 2022.

DOI:10.3389/fnins.2022.905942
PMID:36330349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9624281/
Abstract

BACKGROUND

The impact of migraine without aura (MWoA) on cognitive function remains controversial, especially given the sparse literature on emotional memory.

METHODS

Twenty seven MWoA patients and 25 healthy controls (HCs) were enrolled in this cross-sectional study. Emotional memory behavior was evaluated by combining incidental encoding with intentional encoding of five emotional categories of visual stimulus [positive valence + high arousal (PH), negative valence + high arousal (NH), positive valence + low arousal (PL), negative valence + low arousal (NL), and neutral (N)]. The recollection performance (Pr) was measured and compared. Then, the neural relevance was explored by correlating the Pr with gray matter volume (GMV) and resting-state functional connectivity (rs-FC) based on structural and functional magnetic resonance imaging.

RESULTS

No significant differences in recollection performance or emotional enhancement of memory effect were observed. However, MWoA patients were more sensitive to the valence and arousal of emotional stimuli under incidental encoding. Significantly, the Pr-PH under incidental encoding and Pr-PL under intentional encoding were negatively correlated with the GMV of the left precuneus, and the rs-FC between the left precuneus and putamen was positively correlated with Pr-PL under intentional encoding in MWoA patients.

CONCLUSION

Our study demonstrated the tendency for the influence of migraine on emotional memory and revealed the left precuneus as a critical contributor to recollection performance, providing novel insights for understanding emotional memory and its neural mechanisms in MWoA patients.

摘要

背景

无先兆偏头痛（MWoA）对认知功能的影响仍存在争议，尤其是考虑到关于情绪记忆的文献稀少。

方法

本横断面研究纳入了27例MWoA患者和25名健康对照者（HCs）。通过将视觉刺激的五种情绪类别（正性效价+高唤醒度（PH）、负性效价+高唤醒度（NH）、正性效价+低唤醒度（PL）、负性效价+低唤醒度（NL）和中性（N））的偶发编码与有意编码相结合来评估情绪记忆行为。测量并比较回忆表现（Pr）。然后，基于结构和功能磁共振成像，通过将Pr与灰质体积（GMV）和静息态功能连接（rs-FC）相关联来探索神经相关性。

结果

未观察到回忆表现或记忆效应的情绪增强方面的显著差异。然而，MWoA患者在偶发编码下对情绪刺激的效价和唤醒度更敏感。值得注意的是，偶发编码下的Pr-PH和有意编码下的Pr-PL与左侧楔前叶的GMV呈负相关，并且在MWoA患者中，左侧楔前叶与壳核之间的rs-FC与有意编码下的Pr-PL呈正相关。

结论

我们的研究证明了偏头痛对情绪记忆影响的趋势，并揭示左侧楔前叶是回忆表现的关键贡献者，为理解MWoA患者的情绪记忆及其神经机制提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/aa94b51df209/fnins-16-905942-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/798cc59499e8/fnins-16-905942-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/325dfd7b50af/fnins-16-905942-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/9e1c174c73e6/fnins-16-905942-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/a8fcf9148d0d/fnins-16-905942-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/1a64ab8de8c0/fnins-16-905942-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/aa94b51df209/fnins-16-905942-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/798cc59499e8/fnins-16-905942-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/325dfd7b50af/fnins-16-905942-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/9e1c174c73e6/fnins-16-905942-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/a8fcf9148d0d/fnins-16-905942-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/1a64ab8de8c0/fnins-16-905942-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a49d/9624281/aa94b51df209/fnins-16-905942-g006.jpg

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