CTX-M-2 型超广谱β-内酰胺酶中头孢他啶耐药性演变的实验预测
Experimental prediction of the evolution of ceftazidime resistance in the CTX-M-2 extended-spectrum beta-lactamase.
作者信息
Welsh Kerry J, Barlow Miriam, Tenover Fred C, Biddle James W, Rasheed J Kamile, Clark Leigh Ann, McGowan John E
机构信息
Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd., Atlanta, GA 30322, USA.
出版信息
Antimicrob Agents Chemother. 2005 Mar;49(3):1242-4. doi: 10.1128/AAC.49.3.1242-1244.2005.
Abstract
We applied in vitro evolution to an Escherichia coli strain containing bla(CTX-M-2) and obtained 10 independent mutant bla(CTX-M-2) alleles that confer elevated resistance to ceftazidime (MIC > or = 32 microg/ml) but lost the ability to confer resistance to cefepime. All alleles had a Pro-to-Ser substitution at position 167.
摘要
我们将体外进化技术应用于含有bla(CTX-M-2)的大肠杆菌菌株，获得了10个独立的突变bla(CTX-M-2)等位基因，这些等位基因赋予对头孢他啶的耐药性升高（MIC≥32μg/ml），但失去了赋予对头孢吡肟耐药性的能力。所有等位基因在第167位均有脯氨酸到丝氨酸的替换。
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