Sugawara J, Hayashi K, Yokoi T, Cortez-Cooper M Y, DeVan A E, Anton M A, Tanaka H
Institute for Human Science and Bioengineering, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan.
J Hum Hypertens. 2005 May;19(5):401-6. doi: 10.1038/sj.jhh.1001838.
Brachial-ankle pulse wave velocity (baPWV) is a promising technique to assess arterial stiffness conveniently. However, it is not known whether baPWV is associated with well-established indices of central arterial stiffness. We determined the relation of baPWV with aortic (carotid-femoral) PWV, leg (femoral-ankle) PWV, and carotid augmentation index (AI) by using both cross-sectional and interventional approaches. First, we studied 409 healthy adults aged 18-76 years. baPWV correlated significantly with aortic PWV (r = 0.76), leg PWV (r = 0.76), and carotid AI (r = 0.52). A stepwise regression analysis revealed that aortic PWV was the primary independent correlate of baPWV, explaining 58% of the total variance in baPWV. Additional 23% of the variance was explained by leg PWV. Second, 13 sedentary healthy men were studied before and after a 16-week moderate aerobic exercise intervention (brisk walking to jogging; 30-45 min/day; 4-5 days/week). Reductions in aortic PWV observed with the exercise intervention were significantly and positively associated with the corresponding changes in baPWV (r = 0.74). A stepwise regression analysis revealed that changes in aortic PWV were the only independent correlate of changes in baPWV (beta = 0.74), explaining 55% of the total variance. These results suggest that baPWV may provide qualitatively similar information to those derived from central arterial stiffness although some portions of baPWV may be determined by peripheral arterial stiffness.
肱踝脉搏波速度（baPWV）是一种很有前景的可方便地评估动脉僵硬度的技术。然而，尚不清楚baPWV是否与已确立的中心动脉僵硬度指标相关。我们采用横断面研究和干预性研究方法，确定了baPWV与主动脉（颈动脉 - 股动脉）脉搏波速度、腿部（股动脉 - 踝部）脉搏波速度以及颈动脉增强指数（AI）之间的关系。首先，我们研究了409名年龄在18 - 76岁的健康成年人。baPWV与主动脉脉搏波速度（r = 0.76）、腿部脉搏波速度（r = 0.76）以及颈动脉AI（r = 0.52）显著相关。逐步回归分析显示，主动脉脉搏波速度是baPWV的主要独立相关因素，解释了baPWV总变异的58%。腿部脉搏波速度又额外解释了23%的变异。其次，对13名久坐不动的健康男性在进行为期16周的中等强度有氧运动干预（从快走至慢跑；每天30 - 45分钟；每周4 - 5天）前后进行了研究。运动干预后观察到的主动脉脉搏波速度降低与baPWV的相应变化显著正相关（r = 0.74）。逐步回归分析显示，主动脉脉搏波速度的变化是baPWV变化的唯一独立相关因素（β = 0.74），解释了总变异的55%。这些结果表明，尽管baPWV的某些部分可能由外周动脉僵硬度决定，但baPWV可能提供与中心动脉僵硬度定性相似的信息。
