Curini Massimo, Maltese Federica, Marcotullio Maria Carla, Menghini Luigi, Pagiotti Rita, Rosati Ornelio, Altinier Gianmario, Tubaro Aurelia
Dipartimento di Chimica e Tecnologia del Farmaco, Sez. Chimica Organica, Università degli Studi, Perugia, Italy.
Planta Med. 2005 Feb;71(2):194-6. doi: 10.1055/s-2005-837792.
Glaucopine A (1) and B (2), two new cyathane diterpenes, have been isolated from the mushroom Sarcodon glaucopus: their structures have been determined on the basis of spectral data. Their topical anti-inflammatory activity was evaluated using the Croton oil ear test in mice: compounds 1 and 2 (1 micromol/cm2) provoked edema reduction (62 % and 55 %, respectively) similar to that induced by the reference non-steroidal anti-inflammatory drug, indomethacin (0.3 micromol/cm2, 61 % edema reduction).
从蘑菇灰肉齿菌中分离出了两种新的杯伞烷二萜类化合物——古柯平A（1）和B（2）；已根据光谱数据确定了它们的结构。使用巴豆油耳部试验对小鼠进行局部抗炎活性评估：化合物1和2（1微摩尔/平方厘米）引起的水肿减轻（分别为62%和55%）与参考非甾体抗炎药吲哚美辛（0.3微摩尔/平方厘米，水肿减轻61%）诱导的水肿减轻相似。
