Rudi Amira, Benayahu Yehuda, Kashman Yoel
School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Ramat Aviv 69978, Israel.
J Nat Prod. 2005 Feb;68(2):280-1. doi: 10.1021/np0497550.
Mycgranol, a new isocopalane diterpene (methyl 1beta-hydroxy-2-oxoisocopalanoate) was isolated from the Kenyan sponge Mycale (Aegogropila) aff. graveleyi. The structure of the compound was elucidated by interpretation of MS, COSY, HMQC, HMBC, and ROESY data. The absolute configuration of mycgranol was determined to be the same as that of the nudibranch isocopalane diterpenes rather than that of the ent-compounds known from sponges of the genus Spongia.
从肯尼亚海绵Mycale (Aegogropila) aff. graveleyi中分离出一种新的异柯巴烷二萜（1β-羟基-2-氧代异柯巴烷酸甲酯）——麦考二醇（Mycgranol）。通过对质谱（MS）、化学全相关谱（COSY）、异核多量子相干谱（HMQC）、异核多键相关谱（HMBC）和旋转坐标系下核欧沃豪斯效应谱（ROESY）数据的解析，阐明了该化合物的结构。麦考二醇的绝对构型被确定为与裸鳃亚目异柯巴烷二萜相同，而非与海绵属海绵中已知的对映体化合物相同。
