来自海绵Spongia (Heterofibria) sp.的海绵二萜类化合物

Spongian diterpenoids from the sponge Spongia (Heterofibria) sp.

作者信息

Ponomarenko Ludmila P, Kalinovsky Anatoly I, Afiyatullov Shamil Sh, Pushilin Michail A, Gerasimenko Andrey V, Krasokhin Vladimir B, Stonik Valentin A

机构信息

Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, Vladivostok 690022, Russian Federation.

出版信息

J Nat Prod. 2007 Jul;70(7):1110-3. doi: 10.1021/np070068t. Epub 2007 Jun 14.

DOI:10.1021/np070068t

PMID:17567172

Abstract

Five new (1, 2, 4-6) and one known (3) diterpenoid were isolated from the keratose sponge Spongia (Heterofibria) sp. Structures of these compounds and their absolute configurations were proposed on the basis of X-ray analysis of 1, its CD spectrum, and NMR and MS spectroscopic studies of 1-6. One of the new diterpenoids was shown to be 2(R),3(S),4(S)-3,18-methylene-2-acetoxyspongia-13(16),14-diene (6), possessing a novel carbon skeleton system.

摘要

从角质海绵Spongia (Heterofibria) sp.中分离出5个新的二萜类化合物(1, 2, 4 - 6)和1个已知的二萜类化合物(3)。通过对化合物1进行X射线分析、对其圆二色光谱以及对化合物1 - 6进行核磁共振和质谱光谱研究，确定了这些化合物的结构及其绝对构型。其中一个新的二萜类化合物被证明是2(R),3(S),4(S)-3,18-亚甲基-2-乙酰氧基海绵-13(16),14-二烯(6)，具有一种新颖的碳骨架系统。