Wolff J R, Toldi J, Siklós L, Fehér O, Joó F
Department of Anatomy, Georg-August University, Göttingen, Federal Republic of Germany.
J Comp Neurol. 1992 Mar 8;317(2):187-94. doi: 10.1002/cne.903170207.
This study was carried out to investigate whether correlations existing in normal adult rats (Ambach et al., '86) between functional characteristics of neocortical areas and their pial angioarchitecture can be correspondingly modified under pathological conditions. The right eyes of albino rats were enucleated on the 1st, 8th, 15th and 30th day after birth, respectively. At the age of 3 to 4 months, the responsiveness of the parieto-occipital cortex to sensory stimuli was studied in enucleated animals and age matched controls. After the mapping of visually and somatosensorily evoked potentials, the vascular system was filled with dye. Monocular enucleation at birth induced bilateral modifications in sensory responsiveness and corresponding changes in pial angioarchitecture, especially in the venous drainage fields. In comparison with the controls, a considerable expansion was observed in the overlapping zone between visually and somatosensorily responsive areas. In contrast, borders of the visual cortex toward the auditory and retrosplenial areas were essentially stable. Corresponding changes were found in the pial distribution patterns of cerebral veins but not of arteries. The major effect of neonatal enucleation on angioarchitecture was a change in the subdivision of the parieto-occipital veins drainage fields. This was due to a significant enlargement of the anterior accessory occipital (O3) vein, which compressed the drainage fields of the parietal and occipital veins and completely separated them from one another. The results suggest that during ontogenesis: (1) alterations in the formation of sensory input may interfere with neocortical angiogenesis, especially the structuring of veins, (2) after monocular enucleation this influence is prominent in parietal and occipital cerebral veins, and (3) these angiogenetic processes are vulnerable only during the perinatal and early postnatal period.
本研究旨在调查正常成年大鼠（安巴赫等人，1986年）新皮质区域功能特征与其软脑膜血管结构之间存在的相关性在病理条件下是否会相应改变。分别在出生后第1、8、15和30天摘除白化大鼠的右眼。在3至4个月大时，研究摘除眼球动物和年龄匹配对照中顶枕皮质对感觉刺激的反应性。在绘制视觉和躯体感觉诱发电位后，用染料填充血管系统。出生时单眼摘除引起感觉反应性的双侧改变以及软脑膜血管结构的相应变化，尤其是在静脉引流区域。与对照相比，在视觉和躯体感觉反应区域之间的重叠区域观察到相当大的扩展。相反，视觉皮质朝向听觉和压后皮质区域的边界基本稳定。在脑静脉而非动脉的软脑膜分布模式中发现了相应变化。新生期摘除眼球对血管结构的主要影响是顶枕静脉引流区域细分的改变。这是由于枕前副（O3）静脉显著扩大，其压迫顶叶和枕叶静脉的引流区域并使其完全相互分离。结果表明，在个体发育过程中：（1）感觉输入形成的改变可能干扰新皮质血管生成，尤其是静脉的结构形成；（2）单眼摘除后，这种影响在顶叶和枕叶脑静脉中很突出；（3）这些血管生成过程仅在围产期和出生后早期易受影响。
