Toldi J, Joo F, Feher O, Wolff J R
Department of Comparative Physiology, Jozsef Attila University, Szeged, Hungary.
Neuroscience. 1988 Jan;24(1):59-66. doi: 10.1016/0306-4522(88)90311-9.
Monocular enucleation was performed on rats at birth or on the 8th or 15th day, respectively. The animals were raised and from the age of 3 months the evoked activity was tested in the visual cortex. It was found that monocular enucleation changed the distribution of visually evoked responses. In the right hemisphere (contralateral to the preserved eye) two focuses of evoked potentials appeared with large amplitudes shifted to both sides, towards the lateral and medial borders of the primary visual area. In the left hemisphere the focus of the evoked potentials was shifted slightly laterally and posteriorly. Early enucleation caused an expansion of the somatosensory responses into the visual area. Bimodal neurons (responsive to visual and somatosensory stimuli) were observed in the anterior part of the primary and secondary visual areas contralateral to the enucleation. These changes became moderate with increasing age at which enucleation was performed and were not found in animals enucleated on the 15th day after birth.
分别在出生时、第8天或第15天对大鼠进行单眼摘除。将这些动物饲养至3个月大时，在视觉皮层测试诱发活动。结果发现，单眼摘除改变了视觉诱发反应的分布。在右半球（与保留眼对侧）出现两个诱发电位焦点，其大振幅向两侧移位，朝向初级视觉区的外侧和内侧边界。在左半球，诱发电位焦点略向外侧和后方移位。早期摘除导致体感反应扩展到视觉区。在摘除眼对侧的初级和次级视觉区前部观察到双峰神经元（对视觉和体感刺激有反应）。随着摘除时年龄的增加，这些变化变得缓和，而在出生后第15天摘除的动物中未发现这些变化。
