内皮素在正常和炎症状态下的人牙髓血管内皮中表达的免疫组化证据。

Immunohistochemical evidence for the occurrence of endothelin in the vascular endothelium of normal and inflamed human dental pulp.

作者信息

Casasco A, Casasco M, Ciuffreda M, Springall D R, Calligaro A, Bianchi S, Polak J M

机构信息

Institute of Histology and Embryology, University of Pavia, Italy.

出版信息

J Dent Res. 1992 Mar;71(3):475-7. doi: 10.1177/00220345920710031001.

DOI:10.1177/00220345920710031001

PMID:1573079

Abstract

The occurrence and distribution of the regulatory peptide endothelin in normal and inflamed human dental pulp was studied by immunocytochemistry. Endothelial cells in both normal and inflamed pulp displayed endothelin-like immunoreactivity. Neither pulp cells nor dental nerves were immunoreactive. No significant change in the distribution of endothelin immunoreactivity could be detected in the samples of inflamed pulp tissue, the immunoreactive material being detectable only within the endothelium. However, the intensity of the immunostaining was less intense in the samples of inflamed pulp. It is reasonable to presume that endothelin, produced and released locally by endothelial cells, may participate via a paracrine mechanism in the regulation of blood pressure and flow in normal and pathological human dental tissues.

摘要

采用免疫细胞化学方法研究了调节肽内皮素在正常和炎症状态下的人牙髓中的发生及分布情况。正常牙髓和炎症牙髓中的内皮细胞均显示出内皮素样免疫反应性。牙髓细胞和牙神经均无免疫反应性。在炎症牙髓组织样本中，未检测到内皮素免疫反应性分布有明显变化，免疫反应性物质仅在内皮内可检测到。然而，炎症牙髓样本中的免疫染色强度较弱。可以合理推测，由内皮细胞局部产生和释放的内皮素可能通过旁分泌机制参与正常和病理状态下人类牙齿组织中血压和血流的调节。