Artese Luciano, Rubini Corrado, Ferrero Giuseppina, Fioroni Massimiliano, Santinelli Alfredo, Piattelli Adriano
Dental School, University of Chieti, Italy.
J Endod. 2002 Jan;28(1):20-3. doi: 10.1097/00004770-200201000-00005.
Vascular endothelial growth factor (VEGF) is a glycoprotein that has the capability to increase vascular proliferation and permeability. VEGF has been found to be expressed in several different types of tumors, and it may contribute to the progression of malignant tumors. Immunostaining for VEGF and factor VIII was performed in normal healthy pulps and in irreversible pulpitis. In both cases the vessels were always positive for VEGF. Our immunohistochemical data show that the expression of VEGF was strongly positive in the inflammatory infiltrate in irreversible pulpitis. VEGF expression in the stromal cells in healthy pulps ranged from 20 to 100% (with a mean of 68.82), and in irreversible pulpitis ranged from 0 to 100% (with a mean of 62.35%); this difference was statistically significant (p = 0.05). This down-regulation in the stromal cells in irreversible pulpitis could be due to the presence, in a low compliance system such as the dental pulp, of inflammatory infiltrate. VEGF is probably a factor implicated in the etiology and progression of pulpitis. The microvessel density in healthy pulps was 90.00 +/- 27.5, while, in irreversible pulpitis, it was 56.68 +/- 21.15. This difference was statistically significant (p = 0.001). The decrease in microvessel density in irreversible pulpitis could be related to failing vascular function and blood flow decrease.
血管内皮生长因子（VEGF）是一种糖蛋白，具有促进血管增殖和增加血管通透性的能力。已发现VEGF在几种不同类型的肿瘤中表达，它可能促进恶性肿瘤的进展。对正常健康牙髓和不可逆性牙髓炎进行了VEGF和因子VIII的免疫染色。在这两种情况下，血管对VEGF均呈阳性反应。我们的免疫组化数据显示，在不可逆性牙髓炎的炎症浸润中，VEGF的表达呈强阳性。健康牙髓基质细胞中VEGF的表达范围为20%至100%（平均为68.82），在不可逆性牙髓炎中为0%至100%（平均为62.35%）；这种差异具有统计学意义（p = 0.05）。不可逆性牙髓炎基质细胞中的这种下调可能是由于在牙髓这种低顺应性系统中存在炎症浸润。VEGF可能是牙髓炎病因和进展中的一个相关因素。健康牙髓中的微血管密度为90.00±27.5，而在不可逆性牙髓炎中为56.68±21.15。这种差异具有统计学意义（p = 0.001）。不可逆性牙髓炎中微血管密度的降低可能与血管功能衰竭和血流减少有关。
