Oner Ozgür, Unal Ozlem, Deda Gülhis
Child Psychiatry, Ankara University Faculty of Medicine, 06690 Ankara, Turkey.
Pediatr Neurol. 2005 Mar;32(3):197-200. doi: 10.1016/j.pediatrneurol.2004.10.005.
An 8-year-old male was referred to the child psychiatry department because of vivid visual and auditory hallucinations, including multiple voices talking to each other, and loss of consciousness. Magnetic resonance imaging scans revealed cortical dysgenesis in the left inferior frontal cortex and adjacent subcortical structures. Single-photon emission computed tomography imaging revealed left temporal hypoperfusion. Risperidone therapy was initiated because there was no remission after carbamazepine and sodium valproate treatment. After risperidone treatment, symptoms remitted. A control single-photon emission computed tomography study indicated that the left temporal hypoperfusion was normalized. After discontinuation of risperidone, symptoms returned, and electroencephalography revealed generalized slow-wave activity particularly prominent in the left temporal region. To our knowledge, this is one of the first reports of cerebral blood flow changes in a pediatric patient with psychosis after treatment.
一名8岁男性因生动的视觉和听觉幻觉（包括多个声音相互交谈）以及意识丧失被转诊至儿童精神科。磁共振成像扫描显示左额下回皮质和相邻皮质下结构存在皮质发育异常。单光子发射计算机断层扫描成像显示左颞叶灌注不足。由于卡马西平和丙戊酸钠治疗后症状未缓解，开始使用利培酮治疗。利培酮治疗后，症状缓解。一项对照单光子发射计算机断层扫描研究表明，左颞叶灌注不足已恢复正常。停用利培酮后，症状复发，脑电图显示广泛性慢波活动，在左颞叶区域尤为明显。据我们所知，这是关于精神病患儿治疗后脑血流变化的首批报告之一。
