DeHeer Heather L, McManus Patricia
Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA.
Vet Clin Pathol. 2005;34(1):17-22. doi: 10.1111/j.1939-165x.2005.tb00003.x.
Hemosiderophages may be found in feline tracheal wash specimens in association with various disease conditions, including heart failure, trauma, infection, foreign body migration, lung lobe torsion, pulmonary embolism or infarction, neoplasia, and bleeding diathesis. Based on observations in our laboratory, we hypothesized that tracheal wash specimens from cats with asthma also frequently contain hemosiderophages, even in the absence of other known causes of pulmonary hemorrhage.
The purpose of this study was to determine the frequency and severity of hemosiderosis in tracheal wash fluid from cats with various diseases, including asthma.
Feline tracheal wash fluid specimens submitted for cytologic evaluation between March 2002 and August 2003 were included in the study. One hundred and one specimens from 96 cats were examined with both Wright's-Giemsa and Prussian blue stains. Cats were assigned to 6 disease categories: feline asthma, pneumonia, pulmonary neoplasia, rhinitis, heart disease, and other disorders. Based on the percentage of Prussian blue-positive macrophages, hemosiderosis was categorized as negative (0%), mild (<20%), moderate (21-50%), or marked (>50%).
The frequency of tracheal wash hemosiderosis in the study population was 63.5% (61/96); hemosiderosis was mild (29/96, 30.2%), moderate (22/96, 22.9%), or marked (10/96, 10.4%). Hemosiderosis was found in 85.7% (6/7) of cats with rhinitis, 78.6% (11/14) of cats with pulmonary neoplasia, 75.0% (27/36) of cats with asthma, 71.4% (5/7) of cats with primary or concurrent heart disease, 25.0% (5/20) of cats with pneumonia, and 66.7% (12/18) of cats with other disorders. In cats with asthma, hemosiderosis was usually mild to moderate and frequently was accompanied by increased eosinophils.
The results of this study confirm that hemosiderosis is a common finding in tracheal wash specimens collected from cats with diverse disease conditions, including feline asthma syndrome.
在猫的气管冲洗样本中可发现含铁血黄素巨噬细胞，其与多种疾病状况相关，包括心力衰竭、创伤、感染、异物迁移、肺叶扭转、肺栓塞或梗死、肿瘤以及出血素质。基于我们实验室的观察，我们推测患有哮喘的猫的气管冲洗样本中也经常含有含铁血黄素巨噬细胞，即使在没有其他已知的肺出血原因的情况下。
本研究的目的是确定患有包括哮喘在内的各种疾病的猫的气管冲洗液中含铁血黄素沉着症的频率和严重程度。
纳入2002年3月至2003年8月间提交进行细胞学评估的猫气管冲洗液样本。对来自96只猫的101份样本进行了瑞氏-吉姆萨染色和普鲁士蓝染色检查。猫被分为6种疾病类别：猫哮喘、肺炎、肺肿瘤、鼻炎、心脏病和其他疾病。根据普鲁士蓝阳性巨噬细胞的百分比，含铁血黄素沉着症被分为阴性（0%）、轻度（<20%）、中度（21 - 50%）或重度（>50%）。
研究人群中气管冲洗含铁血黄素沉着症的频率为63.5%（61/96）；含铁血黄素沉着症为轻度（29/96，30.2%）、中度（22/96，22.9%）或重度（10/96，10.4%）。在患有鼻炎的猫中，85.7%（6/7）发现含铁血黄素沉着症；在患有肺肿瘤的猫中，78.6%（11/14）；在患有哮喘的猫中，75.0%（27/36）；在患有原发性或并发性心脏病的猫中，71.4%（5/7）；在患有肺炎的猫中，25.0%（5/20）；在患有其他疾病的猫中，66.7%（12/18）。在患有哮喘的猫中，含铁血黄素沉着症通常为轻度至中度，并且经常伴有嗜酸性粒细胞增多。
本研究结果证实，含铁血黄素沉着症是从患有多种疾病状况（包括猫哮喘综合征）的猫收集的气管冲洗样本中的常见发现。
