Taradi S K, Taradi M, Urano M
Department of Radiation Medicine, University of Kentucky, Lexington 40536-0084.
Int J Hyperthermia. 1992 Mar-Apr;8(2):221-6. doi: 10.3109/02656739209021777.
The effect of combined hyperthermia and intratumoral administration of OK-432 (Picibanil) on the development of spontaneous lung metastases was studied. The spontaneous non-immunogenic fibrosarcoma, FSa-II, transplanted into the right foot of C3Hf/Sed mice, was used throughout. Hyperthermia was given locally by immersing the animal foot in a water bath set at 44.0 degrees C for 30 min. OK-432 in the dose of 2.5 KE was injected into the tumour 3 h before hyperthermia. This treatment has been shown to strongly inhibit local tumour growth. Sham hyperthermia, i.e. restraining the mice in holders, as well as local injection of saline solution, increased metastases incidence. The high incidence of metastases following combined sham hyperthermia and saline injection was substantially reduced by intratumoral administration of OK-432 given alone or combined with hyperthermia.
研究了热疗与瘤内注射OK-432（匹鲁卡品）联合应用对自发性肺转移瘤发展的影响。自始至终使用移植到C3Hf/Sed小鼠右足的自发性非免疫原性纤维肉瘤FSa-II。通过将动物足部浸入设定为44.0℃的水浴中30分钟进行局部热疗。在热疗前3小时将剂量为2.5KE的OK-432注入肿瘤。已证明这种治疗可强烈抑制局部肿瘤生长。假热疗，即将小鼠固定在固定器中，以及局部注射生理盐水，会增加转移发生率。单独瘤内注射OK-432或与热疗联合应用，可显著降低假热疗与盐水注射联合应用后转移的高发生率。
