Ando K, Urano M, Kenton L, Kahn J
Edwin L. Steele Laboratory, Department of Radiation Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02114.
Int J Hyperthermia. 1987 Sep-Oct;3(5):453-8. doi: 10.3109/02656738709140415.
Effect of local hyperthermia given alone or in combination with cyclophosphamide and/or hyperglycaemia on the development of lung metastasis was studied using a non-immunogenic mouse fibrosarcoma, FSa-II. Incidence of lung metastasis was dependent upon the tumour size, and was increased when tumour-bearing mice were restrained in animal holders which were used for heat-treatment of animal tumours. The frequency of the metastatic spread was decreased following local hyperthermia at 41.5 degrees and 45.5 degrees C when compared to that following sham treatment. This decrease was independent of the heat dose. Similar reduction in the incidence of metastasis was observed after hyperthermia given following glucose administration. The administration of cyclophosphamide effectively inhibited the development of lung metastasis. However, the magnitude of the inhibition was identical to that following hyperthermia alone. In conclusion, hyperthermia given alone, or in combination with hyperglycaemia or cyclophosphamide, inhibited the development of lung metastasis.
采用非免疫原性小鼠纤维肉瘤FSa-II，研究单独给予局部热疗或联合环磷酰胺和/或高血糖对肺转移发生的影响。肺转移的发生率取决于肿瘤大小，当荷瘤小鼠被限制在用于动物肿瘤热处理的动物固定器中时，肺转移发生率会增加。与假处理相比，41.5摄氏度和45.5摄氏度局部热疗后转移扩散频率降低。这种降低与热剂量无关。给予葡萄糖后进行热疗，转移发生率也有类似降低。环磷酰胺的给药有效抑制了肺转移的发生。然而，抑制程度与单独热疗后的相同。总之，单独给予热疗，或与高血糖或环磷酰胺联合使用，均可抑制肺转移的发生。
