May Christian Albrecht, Skorski Liliana Maria, Lütjen-Drecoll Elke
Department of Anatomy II, Friedrich Alexander University Erlangen-Nuernberg, Erlangen, Germany.
J Anat. 2005 Mar;206(3):231-6. doi: 10.1111/j.1469-7580.2005.00388.x.
The porcine eye serves as a model to study various functions of the aqueous outflow system. To compare these data with the primate eye, a detailed investigation of the distribution of contractile properties and of the innervation of the outflow region was conducted in the porcine eye. In all quadrants of the anterior eye segment, elastic fibres connected the ciliary muscle (CM) with the well-developed scleral spur (ScS) and also partly with the corneoscleral trabecular meshwork (TM) and the loops of the collecting outflow channels. Immunohistochemistry with antibodies against smooth muscle alpha-actin revealed intense staining of the CM and some myofibroblasts in the ScS and outer TM. In addition to a few cholinergic and aminergic nerve fibres in the outflow region, numerous substance P- and calcitonin-gene related peptide-positive nerve fibres and nerve endings were found near the outflow loops of the porcine TM. Although the porcine CM serves rather as a tensor choroideae muscle than as a muscle for accommodation, the innervation and morphology of the collecting outflow channel loops and of the expanded TM between the ScS and the cornea showed close similarities to the primate eye.
猪眼作为研究房水流出系统各种功能的模型。为了将这些数据与灵长类动物的眼睛进行比较，对猪眼流出区域的收缩特性分布和神经支配进行了详细研究。在前房段的所有象限中，弹性纤维将睫状肌（CM）与发育良好的巩膜突（ScS）相连，也部分地与角膜巩膜小梁网（TM）和收集流出通道的环相连。用抗平滑肌α-肌动蛋白抗体进行免疫组织化学显示，CM以及ScS和外TM中的一些肌成纤维细胞有强烈染色。除了流出区域有一些胆碱能和胺能神经纤维外，在猪TM流出环附近还发现了大量P物质和降钙素基因相关肽阳性神经纤维和神经末梢。尽管猪的CM更像是脉络膜张肌而不是调节肌，但收集流出通道环以及ScS和角膜之间扩展的TM的神经支配和形态与灵长类动物的眼睛有密切相似之处。
