Thomas L H
Department of Science and Chemical Engineering, Polytechnic of Wales, Pontypridd, Mid-Glamorgan, United Kingdom.
J Epidemiol Community Health. 1992 Feb;46(1):78-82. doi: 10.1136/jech.46.1.78.
The aim was to examine the hypothesis that hydrogenated fats, particularly those obtained from marine oils, may present a health hazard.
Storage fat specimens obtained at necropsy were collected from several areas in England and Wales during 1975-1978. Cases (n = 136 samples) consisted of males dying of ischaemic heart disease, male deaths from unrelated causes acting as controls (n = 95 samples). The fatty acid compositions of the specimens were determined, and analysis included those acids--16:1 trans and "higher" C-20 plus C-22 (H)--highly characteristic of partially hydrogenated marine oils.
The case samples, which had been shown to be the richer in 16:1 trans (p less than 0.005), were now found to have a significantly higher value of the ratio 16:1 trans to H (p less than 0.002), arising from consumption of differing hydrogenated marine oil types.
It is concluded that the cases had consumed a greater amount (p less than 0.001) of hydrogenated marine oils of a certain type, ie, that manufactured from certain highly unsaturated raw oils. The process of partial hydrogenation results in conversion to a product containing large amounts of polyunsaturated acids (PUFA) which are no longer in the natural all-cis methylene interrupted configuration. Such isomeric PUFA may obstruct or compete with utilisation of natural PUFA. It is further concluded that the case excess did not rise from medical advice favouring margarine or from any difference in social class status, but rather from fortuitous selection of margarine brand.
本研究旨在验证氢化脂肪，尤其是从海洋油中提取的氢化脂肪可能对健康有害这一假设。
1975年至1978年期间，从英格兰和威尔士的多个地区收集了尸检时获得的储存脂肪样本。病例组（n = 136个样本）由死于缺血性心脏病的男性组成，对照组（n = 95个样本）为死于其他无关原因的男性。测定了样本的脂肪酸组成，分析包括那些具有部分氢化海洋油高度特征的酸——反式16:1和“高级”C - 20加C - 22（H）。
病例组样本已被证明富含反式16:1（p < 0.005），现在发现其反式16:1与H的比值显著更高（p < 0.002），这是由于食用了不同类型的氢化海洋油。
得出的结论是，病例组食用了更多（p < 0.001）特定类型的氢化海洋油，即由某些高度不饱和原油制成的氢化海洋油。部分氢化过程导致转化为一种含有大量多不饱和脂肪酸（PUFA）的产品，这些多不饱和脂肪酸不再处于天然的全顺式亚甲基间断构型。这种异构的PUFA可能会阻碍或与天然PUFA的利用竞争。进一步得出的结论是，病例组的过量摄入并非源于推荐使用人造黄油的医学建议，也不是源于社会阶层地位的任何差异，而是源于偶然选择的人造黄油品牌。
