Nugent A P
Nutrition Scientist, British Nutrition Foundation, High Holborn House, 52-54 High Holborn, London WC1V 6RQ, UK.
Biochimie. 2005 Jan;87(1):129-32. doi: 10.1016/j.biochi.2004.10.024.
LIPGENE is a new 5-year sixth framework EU project involving researchers from 14 EU countries. It will contribute to a reduction in the economic and social burden of the metabolic syndrome through research that will optimise the health impacts of dietary fat change. LIPGENE aims to: account for variation in genotype response to fatty acid modification; enable greater availability of food products that can enhance human health; enhance consumer awareness, and motivate adoption of dietary approaches to disease prevention. A truly integrated programme, LIPGENE incorporates human nutrition, animal nutrition, plant biotechnology, and economic and social/consumer sciences. The human nutrition packages will utilise data from an existing prospective study (SUVIMAX) to identify genotype and dietary interactions as risk factors for the metabolic syndrome. A multi-centre intervention will examine the effects of dietary fat on various risk factors for the metabolic syndrome, while molecular investigations will be supported by mechanistic and functional studies. The British Nutrition Foundation, as dissemination partners for this EU programme, is initiating a wide-reaching programme to disseminate information about the project and its findings. Further details, including lists of upcoming project-related events, are available at www.lipgene.tcd.ie and www.nutrition.org.uk/lipgene.
LIPGENE是一项为期5年的全新欧盟第六框架项目，有来自14个欧盟国家的研究人员参与其中。该项目将通过优化膳食脂肪变化对健康影响的研究，为减轻代谢综合征的经济和社会负担做出贡献。LIPGENE的目标是：解释基因型对脂肪酸修饰反应的差异；使有助于增进人类健康的食品更易获取；提高消费者意识，并促使人们采用饮食方法预防疾病。作为一个真正的综合项目，LIPGENE整合了人类营养、动物营养、植物生物技术以及经济和社会/消费者科学。人类营养项目包将利用一项现有前瞻性研究（SUVIMAX）的数据，来确定基因型与饮食的相互作用，将其作为代谢综合征的风险因素。一项多中心干预研究将考察膳食脂肪对代谢综合征各种风险因素的影响，同时分子研究将得到机制和功能研究的支持。英国营养基金会作为该欧盟项目的传播合作伙伴，正在启动一项广泛的计划，以传播有关该项目及其研究结果的信息。更多详细信息，包括即将举行的与项目相关活动的列表，可在www.lipgene.tcd.ie和www.nutrition.org.uk/lipgene上获取。
