Villate Natalia, Lee Ji Eun, Venkatraman Anna, Smiddy William E
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida 33136, USA.
Am J Ophthalmol. 2005 Feb;139(2):280-9. doi: 10.1016/j.ajo.2004.09.029.
Study correlation between optical coherence tomography (OCT) findings and visual acuity (VA) outcomes after successful macular hole surgery (MHS).
Retrospective cross-sectional study.
Postoperative OCT scans were analyzed in 34 eyes of 30 patients. Raw files of horizontal and vertical OCT scans were exported to Adobe Photoshop 7.0. Measured parameters included central foveal thickness, photoreceptor thickness, photoreceptor reflectivity, and relative reflectivity of photoreceptor to retinal pigment epithelium in the foveal area. Foveal configuration was subjectively graded.
OCT scans were obtained at a median of 2 years (1 month to 10 years) postoperatively. The median visual acuity was 20/80 (20/50 to 8/200) preoperatively and 20/50 (20/20 to 5/200) postoperatively. The median foveal thickness was 198.5 micro (148 to 283). The mean (SD) photoreceptor layer thickness was 16.5 (8) micro in the 500 micro area and 17.5 (8) micro in the 1000 micro area. Mean (SD) of relative reflectivity of the photoreceptor layer was 0.60 (0.10) in both 500 micro and 1000 micro area. Postoperative VA did not correlate with foveal thickness or foveal configuration. Central (500 micro and 1000 micro) photoreceptor thickness was significantly correlated with final VA (r = .38, P = .026, each). Relative reflectivity of photoreceptors to retinal pigment epithelium in the 500 micro area was correlated with postoperative VA at a borderline significance (r = .32, P = .07). Relative reflectivity of photoreceptors to retinal pigment epithelium in the 1000 micro area was not significantly correlated with postoperative VA (r = .27, P = .12).
Specific retinal features can be assessed from OCT images. Morphology and thickness of the foveal photoreceptor layer correlate well with macular function after successful MHS. Outer retinal features appear to be more important to determine postoperative visual function. Inner retinal features may be more relevant for the ophthalmoscopic appearance of anatomic closure.
研究黄斑裂孔手术（MHS）成功后光学相干断层扫描（OCT）结果与视力（VA）预后之间的相关性。
回顾性横断面研究。
对30例患者的34只眼进行术后OCT扫描分析。将水平和垂直OCT扫描的原始文件导出到Adobe Photoshop 7.0。测量参数包括中央凹厚度、光感受器厚度、光感受器反射率以及中央凹区域光感受器与视网膜色素上皮的相对反射率。对中央凹形态进行主观分级。
术后OCT扫描的中位时间为2年（1个月至10年）。术前中位视力为20/80（20/50至8/200），术后为20/50（20/20至5/200）。中央凹厚度中位数为198.5微米（148至283）。在500微米区域，光感受器层平均（标准差）厚度为16.5（8）微米，在1000微米区域为17.5（8）微米。在500微米和1000微米区域，光感受器层相对反射率的平均（标准差）均为0.60（0.10）。术后视力与中央凹厚度或中央凹形态无关。中央（500微米和1000微米）光感受器厚度与最终视力显著相关（r = 0.38，P = 0.026，两者均如此）。500微米区域光感受器与视网膜色素上皮的相对反射率与术后视力呈临界显著相关（r = 0.32，P = 0.07）。1000微米区域光感受器与视网膜色素上皮的相对反射率与术后视力无显著相关性（r = 0.27，P = 0.12）。
可从OCT图像评估特定的视网膜特征。成功的黄斑裂孔手术后，中央凹光感受器层的形态和厚度与黄斑功能密切相关。视网膜外层特征似乎对确定术后视觉功能更为重要。视网膜内层特征可能与解剖学闭合的检眼镜表现更相关。
