Zhang Peng, Shang Qingli, Ma Jingxue, Hao Yuhua, Ye Cunxi
Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province - China.
Eur J Ophthalmol. 2017 Nov 8;27(6):781-785. doi: 10.5301/ejo.5000953.
To determine the correlation between the preoperative basal diameter of macular hole, the postoperative area of high autofluorescence (AF) in macula, and visual acuity in full-thickness macular hole.
Forty-nine patients with full-thickness macular hole who underwent vitrectomy and CF filling were reviewed. The preoperative diameter of macular hole, the 6 months postoperative area of high AF in macula if it existed, the length of inner segment/outer segment (IS/OS) defect, and visual acuity were obtained. The correlation between them was determined.
At postoperative 6 months, the rate of high AF in macula was 63.3%. There were statistical differences between with and without high AF groups in postoperative best-corrected visual acuity (BCVA) (t = -2.751, p = 0.008), preoperative basal diameter of macular hole (t = -4.946, p = 0.00001), and postoperative length of IS/OS defect (t = -8.351, p<0.00001). Simple linear regression analysis showed high positive correlations between preoperative basal diameter of macular hole and area of high AF (p<0.00001, r = 0.893), postoperative length of IS/OS defect and area of high fundus AF (FAF) (p<0.00001, r = 0.779), and negative correlations between area of high AF and postoperative BCVA (p = 0.037, r = 0.375). There was low correlation between diameter of macular hole and postoperative BCVA (p = 0.112).
The preoperative basal diameter of macular hole and postoperative length of IS/OS defect decides the postoperative area of high AF in macula to some degree, and the postoperative area of high AF in macula can be an evaluating indicator for poor macular function recovery.
确定全层黄斑裂孔术前黄斑裂孔基底直径、术后黄斑区高自发荧光（AF）面积与视力之间的相关性。
回顾性分析49例行玻璃体切除术联合惰性气体填充的全层黄斑裂孔患者。记录术前黄斑裂孔直径、术后6个月黄斑区高AF面积（若存在）、内节/外节（IS/OS）缺损长度及视力。确定它们之间的相关性。
术后6个月，黄斑区高AF发生率为63.3%。黄斑区有无高AF组在术后最佳矫正视力（BCVA）（t = -2.751，p = 0.008）、术前黄斑裂孔基底直径（t = -4.946，p = 0.00001）及术后IS/OS缺损长度（t = -8.351，p<0.00001）方面存在统计学差异。简单线性回归分析显示，术前黄斑裂孔基底直径与高AF面积呈高度正相关（p<0.00001，r = 0.893），术后IS/OS缺损长度与眼底高自发荧光（FAF）面积呈高度正相关（p<0.00001，r = 0.779），高AF面积与术后BCVA呈负相关（p = 0.037，r = 0.375）。黄斑裂孔直径与术后BCVA相关性较低（p = 0.112）。
术前黄斑裂孔基底直径和术后IS/OS缺损长度在一定程度上决定了术后黄斑区高AF面积，术后黄斑区高AF面积可作为黄斑功能恢复不良的评估指标。
