Miki Atsushi, Nakajima Takashi, Takagi Mineo, Usui Tomoaki, Abe Haruki, Liu Chia-Shang J, Liu Grant T
Division of Ophthalmology and Visual Sciences, Niigata University, Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Am J Ophthalmol. 2005 Feb;139(2):353-6. doi: 10.1016/j.ajo.2004.07.042.
To examine the occipital-lobe activation of patients with optic neuritis using near-infrared spectroscopy.
Experimental study.
NIRS was performed on five patients with acute unilateral optic neuritis during monocular visual stimulation. As controls, six normal subjects were also tested in the same manner.
In the patients with optic neuritis, the changes in the hemoglobin concentrations (oxyhemoglobin, deoxyhemoglobin, and total hemoglobin) in the occipital lobe were found to be markedly reduced when the clinically affected eyes were stimulated compared with the fellow eyes. The response induced by the stimulation of the affected eye was decreased, even when the patient's visual acuity improved to 20/20 in the recovery phase. There was no difference in the concentration changes between the two eyes in the control subjects.
NIRS may be useful in detecting visual dysfunction objectively and noninvasively in patients with visual disturbance, especially when used at the bedside.
使用近红外光谱技术检测视神经炎患者枕叶的激活情况。
实验研究。
对5例急性单侧视神经炎患者在单眼视觉刺激期间进行近红外光谱检查。作为对照，6名正常受试者也以相同方式进行测试。
在视神经炎患者中，发现与健侧眼相比，当患侧眼受到刺激时，枕叶血红蛋白浓度（氧合血红蛋白、脱氧血红蛋白和总血红蛋白）的变化明显降低。即使在恢复阶段患者视力提高到20/20，患侧眼刺激所诱发的反应仍降低。对照组受试者双眼之间的浓度变化无差异。
近红外光谱技术可能有助于客观、无创地检测视力障碍患者的视觉功能障碍，特别是在床边使用时。
