Weil Gary J, Ramzy Reda M R
Infectious Diseases Division, Washington University School of Medicine, Campus Box 8051, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Trends Parasitol. 2007 Feb;23(2):78-82. doi: 10.1016/j.pt.2006.12.001. Epub 2006 Dec 14.
The ambitious and exciting Global Programme to Eliminate Lymphatic Filariasis (GPELF) is largely based on a strategy of mass drug administration (MDA) of repeated rounds of antifilarial medications to endemic populations around the world. Diagnostic tools are important to GPELF because they affect decisions regarding where to distribute MDA, how to measure its effects, how to define targets and endpoints for stopping MDA, and how to monitor populations for possible resurgence of filariasis transmission following suspension of MDA. This article reviews available diagnostic tests for filariasis and their potential use as tools for different phases of filariasis elimination programs.
雄心勃勃且令人振奋的全球消除淋巴丝虫病规划（GPELF）主要基于一项战略，即对世界各地的流行人群反复进行多轮抗丝虫药物的大规模药物给药（MDA）。诊断工具对GPELF很重要，因为它们会影响关于在何处开展MDA、如何衡量其效果、如何确定停止MDA的目标和终点，以及如何监测人群以发现MDA暂停后丝虫病传播可能卷土重来等方面的决策。本文综述了现有的丝虫病诊断检测方法及其作为丝虫病消除计划不同阶段工具的潜在用途。
