Harel François, Dupuis Jocelyn, Benelfassi Ahmed, Ruel Nathalie, Grégoire Jean
Montreal Heart Institute, 5000 Belanger St., Montreal, Quebec, Canada H1T 1C8.
Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H258-62. doi: 10.1152/ajpheart.01021.2004. Epub 2005 Feb 25.
We validated a noninvasive radionuclide plethysmography technique to evaluate peripheral arterial blood flow during reactive hyperemia. This method, based on the measurement of blood volume variations during repetitive venous occlusions, was compared with strain-gauge venous impedance plethysmography. The technique uses 99mTc-labeled autologous red blood cells scintigraphy to determine the rate of change of forearm scintigraphic counts during venous occlusion. Thirteen subjects were simultaneously evaluated with radionuclide and impedance plethysmography. Six baseline flow measurements were performed to evaluate the reproducibility of each method. Twenty-seven serial measurements were then made to evaluate flow variation during forearm reactive hyperemia. After 30 min of recovery, resting forearm blood flows were again evaluated. Impedance and radionuclide methods showed excellent reproducibility with intraclass correlation coefficients of 0.96 and 0.93, respectively. There was also good correlation of flows between both methods during reactive hyperemia (r = 0.87). Resting flows at 30 min after reactive hyperemia were slightly lower than at baseline with both methods. We conclude that radionuclide plethysmography could be used for the noninvasive evaluation of forearm blood flow and its dynamic variations during reactive hyperemia.
我们验证了一种无创放射性核素体积描记术，用于评估反应性充血期间的外周动脉血流。该方法基于重复静脉阻塞期间血容量变化的测量，并与应变片静脉阻抗体积描记术进行了比较。该技术使用99mTc标记的自体红细胞闪烁显像来确定静脉阻塞期间前臂闪烁显像计数的变化率。13名受试者同时接受了放射性核素和阻抗体积描记术评估。进行了6次基线血流测量以评估每种方法的可重复性。然后进行了27次连续测量，以评估前臂反应性充血期间的血流变化。恢复30分钟后，再次评估静息前臂血流。阻抗法和放射性核素法显示出极好的可重复性，组内相关系数分别为0.96和0.93。在反应性充血期间，两种方法之间的血流也具有良好的相关性（r = 0.87）。两种方法在反应性充血后30分钟时的静息血流均略低于基线水平。我们得出结论，放射性核素体积描记术可用于无创评估前臂血流及其在反应性充血期间的动态变化。
