Janssens A S, Heide R, den Hollander J C, Mulder P G M, Tank B, Oranje A P
Department of Dermatology and Venereology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
J Clin Pathol. 2005 Mar;58(3):285-9. doi: 10.1136/jcp.2004.017210.
To investigate mast cell distribution in normal adult skin to provide a reference range for comparison with mastocytosis.
Mast cells (MCs) were counted in uninvolved skin adjacent to basal cell carcinomas and other dermatological disorders in adults.
There was an uneven distribution of MCs in different body sites using the anti-tryptase monoclonal antibody technique. Numbers of MCs on the trunk, upper arm, and upper leg were similar, but were significantly different from those found on the lower leg and forearm. Two distinct groups were formed--proximal and distal. There were 77.0 MCs/mm2 at proximal body sites and 108.2 MCs/mm2 at distal sites. Adjusted for the adjacent diagnosis and age, this difference was consistent. The numbers of MCs in uninvolved skin adjacent to basal cell carcinomas and other dermatological disorders were not different from those in the control group. Differences in the numbers of MCs between the distal and the proximal body sites must be considered when MCs are counted for a reliable diagnosis of mastocytosis. A pilot study in patients with mastocytosis underlined the variation in the numbers of MCs in mastocytosis and normal skin, but showed a considerable overlap. The observed numbers of MCs in adults cannot be extrapolated to children.
MC numbers varied significantly between proximal and distal body sites and these differences must be considered when MCs are counted for a reliable diagnosis of mastocytosis. There was a considerable overlap between the numbers of MCs in mastocytosis and normal skin.
研究正常成人皮肤中肥大细胞的分布情况，为与肥大细胞增多症进行比较提供参考范围。
对成人基底细胞癌及其他皮肤病灶周围未受累皮肤中的肥大细胞进行计数。
采用抗胰蛋白酶单克隆抗体技术，发现肥大细胞在不同身体部位分布不均。躯干、上臂和大腿的肥大细胞数量相似，但与小腿和前臂的肥大细胞数量有显著差异。形成了两个不同的组——近端组和远端组。近端身体部位的肥大细胞数量为77.0个/mm²，远端部位为108.2个/mm²。经相邻诊断和年龄校正后，这种差异仍然存在。基底细胞癌及其他皮肤病灶周围未受累皮肤中的肥大细胞数量与对照组无异。在对肥大细胞增多症进行可靠诊断而计数肥大细胞时，必须考虑远端和近端身体部位肥大细胞数量的差异。一项针对肥大细胞增多症患者的初步研究强调了肥大细胞增多症患者和正常皮肤中肥大细胞数量的变化，但显示出相当大的重叠。在成人中观察到的肥大细胞数量不能外推至儿童。
近端和远端身体部位的肥大细胞数量差异显著，在对肥大细胞增多症进行可靠诊断而计数肥大细胞时，必须考虑这些差异。肥大细胞增多症患者和正常皮肤中的肥大细胞数量有相当大的重叠。
