Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Interdepartmental University Center of Research "Adaption and Regeneration of Tissues and Organs - ARTO", University of Brescia, Brescia, Italy.
J Histochem Cytochem. 2024 Mar;72(3):157-171. doi: 10.1369/00221554241236537. Epub 2024 Mar 5.
Skin sensitivity and impaired epidermal barrier function are associated with aging and are at least partly due to increased production of reactive oxygen species (ROS). Transient receptor potential vanilloid1 (TRPV1) is expressed in keratinocytes, fibroblasts, mast cells, and endothelial cells in skin. We investigated in skin biopsies of adult and elderly donors whether TRPV1 expression is involved in the skin aging process. We found that aging skin showed a strongly reduced epidermal thickness, strongly increased oxidative stress, protease expression, and mast cell degranulation and strongly increased TRPV1 expression both in epidermis and dermis. Based on our findings, the aging-related changes observed in the epidermis of the skin level are associated with increased ROS production, and hypothesized alterations in TRPV1 expression are mechanistically linked to this process.
皮肤敏感性和表皮屏障功能受损与衰老有关，至少部分原因是活性氧（ROS）的产生增加。瞬时受体电位香草素 1（TRPV1）在皮肤中的角质形成细胞、成纤维细胞、肥大细胞和内皮细胞中表达。我们在成年和老年供体的皮肤活检中研究了 TRPV1 表达是否参与皮肤衰老过程。我们发现，衰老的皮肤表现出强烈的表皮厚度减少、强烈的氧化应激、蛋白酶表达、肥大细胞脱颗粒和表皮和真皮中 TRPV1 表达的强烈增加。基于我们的发现，皮肤表皮水平观察到的与衰老相关的变化与 ROS 产生增加有关，并且假设 TRPV1 表达的改变与该过程在机制上相关。
