Körber A, Grabbe S, Dissemond J
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen.
Hautarzt. 2005 Sep;56(9):860-5. doi: 10.1007/s00105-005-0915-8.
Human antimicrobial peptides play a substantial role in the immune response to various dermatological diseases, such as acne, atopic dermatitis and psoriasis vulgaris, and even mucosal HIV-protection is mediated inter alia by antimicrobial peptides. In wound healing, the antimicrobial and immune-modulating properties of, in particular, human defensins and cathelicidins can affect important controlling factors. For example, the interaction between different antimicrobial peptides and growth factors supports neoangiogenesis. Although further clinical investigations are necessary to identify the exact effects of antimicrobial peptides in chronic wounds, such peptides could be a promising therapeutic option in the near future for the treatment of patients with chronic wounds by promoting endogen expression or exogenous supplementation.
人类抗菌肽在对各种皮肤病（如痤疮、特应性皮炎和寻常型银屑病）的免疫反应中发挥着重要作用，甚至黏膜的HIV保护也尤其由抗菌肽介导。在伤口愈合过程中，特别是人类防御素和cathelicidins的抗菌和免疫调节特性会影响重要的控制因素。例如，不同抗菌肽与生长因子之间的相互作用有助于新血管生成。尽管需要进一步的临床研究来确定抗菌肽在慢性伤口中的确切作用，但通过促进内源性表达或外源性补充，这类肽在不久的将来可能成为治疗慢性伤口患者的一种有前景的治疗选择。
