Hui P W, Tang M H Y, Lam Y H, Yeung W S B, Ng E H Y, Ho P C
Department of Obstetrics and Gynaecology, Queen Mary Hospital, Hong Kong, China.
Ultrasound Obstet Gynecol. 2005 Mar;25(3):234-8. doi: 10.1002/uog.1846.
Levels of maternal serum markers of fetal Down syndrome in pregnancies conceived after assisted reproduction are different from those of normal spontaneous pregnancies. The present study examined the effects of conventional in-vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) and embryo cryopreservation on nuchal translucency (NT) thickness.
A retrospective analysis on 16 673 spontaneous pregnancies, 119 pregnancies with fresh embryos from IVF, 62 pregnancies with frozen-thawed embryos from IVF, 81 pregnancies with fresh embryos from ICSI and 39 frozen-thawed embryos from ICSI was performed. All were singletons with known normal outcomes. Multiples of the median (MoM) of NT were compared.
The median NT MoM of spontaneous pregnancies was 1.01. In the assisted reproduction pregnancies, the median NT MoM were significantly increased to 1.07 (P = 0.003), 1.09 (P = 0.009) and 1.09 (P = 0.001) in pregnancies conceived with fresh embryos from IVF, frozen-thawed embryos from IVF and fresh embryos from ICSI, respectively. A non-significant increase in median NT MoM (1.04; P = 0.489) was also observed in pregnancies with frozen-thawed embryos from ICSI.
Increased NT in assisted reproduction pregnancies is postulated to be due to some delay in fetal development. Another possible reason might be related to adverse antenatal course in these pregnancies.
辅助生殖后妊娠的胎儿唐氏综合征母体血清标志物水平与正常自然妊娠不同。本研究探讨了常规体外受精（IVF）、卵胞浆内单精子注射（ICSI）和胚胎冷冻保存对颈项透明层（NT）厚度的影响。
对16673例自然妊娠、119例IVF新鲜胚胎妊娠、62例IVF冻融胚胎妊娠、81例ICSI新鲜胚胎妊娠和39例ICSI冻融胚胎妊娠进行回顾性分析。所有均为单胎且结局已知正常。比较NT的中位数倍数（MoM）。
自然妊娠的NT MoM中位数为1.01。在辅助生殖妊娠中，IVF新鲜胚胎妊娠、IVF冻融胚胎妊娠和ICSI新鲜胚胎妊娠的NT MoM中位数分别显著增加至1.07（P = 0.003）、1.09（P = 0.009）和1.09（P = 0.001）。ICSI冻融胚胎妊娠的NT MoM中位数也有非显著性增加（1.04；P = 0.489）。
辅助生殖妊娠中NT增加推测是由于胎儿发育有些延迟。另一个可能的原因可能与这些妊娠的不良产前过程有关。
