Department of Obstetrics and Gynecology; Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
JBRA Assist Reprod. 2022 Apr 17;26(2):329-334. doi: 10.5935/1518-0557.20210088.
To investigate the incidence of fetal heart defects in assisted reproductive technology (ART)-induced pregnancies compared to natural pregnancies as well as to detect their fetal and maternal risk factors associated with ART.
In this retrospective cohort study, we collected data from the medical records belonging to 2877 pregnant women's fetuses, who underwent fetal echocardiography for various reasons, including ART, over the last 3 years.
There were no major cardiac anomaly in the ART-induced pregnancies, while it was seen in 1.32% of natural pregnancies; so, ART did not increase the risk of major cardiac anomalies. However, the incidence of fetal mild cardiac anomalies among fetuses derived from ART-induced pregnancies (51.43%) was significantly higher than that of natural pregnancies (44.43%, p=0.03). None of the ART-induced pregnancies had a history of a child with cardiac disease (vs. 7.56% in natural pregnancies). Also, the increased nuchal thickness (NT) and extra-cardiac anomalies were significantly more prevalent among natural pregnancies, indicating a significant negative correlation between ART and these two risk factors [χ2=10.24, r: -0.06, 95% CI(-0.0974 to -0.0221) and χ2=47.25, r: -0.129, 95% CI(-0.1656 to -0.0913), p<0.01, respectively]. The adjusted odds ratio of developing fetal mild cardiac anomalies were 1.37 times higher greater for ART-induced pregnancies compared to natural pregnancies [95% CI(1.072-1.769), p=0.01].
Although the likelihood of developing fetal mild cardiac anomalies was 1.37 times higher for ART-induced pregnancy compared to natural pregnancy, ART did not increase the risk of major cardiac anomalies Although the likelihood of developing fetal mild cardiac anomalies was 1.37 times higher for ART-induced pregnancy compared to natural pregnancy, ART did not increase the risk of major cardiac anomalies.
研究辅助生殖技术（ART）妊娠与自然妊娠胎儿心脏缺陷的发生率，并检测与 ART 相关的胎儿和母体危险因素。
在这项回顾性队列研究中，我们收集了过去 3 年来因各种原因接受胎儿超声心动图检查的 2877 名孕妇胎儿的病历数据。
ART 诱导妊娠中无重大心脏畸形，而自然妊娠中为 1.32%；因此，ART 并未增加重大心脏畸形的风险。然而，ART 诱导妊娠胎儿轻度心脏畸形的发生率（51.43%）明显高于自然妊娠（44.43%，p=0.03）。ART 诱导妊娠中无一例有先心病患儿病史（自然妊娠中为 7.56%）。此外，自然妊娠中颈后透明带（NT）增厚和心脏外畸形明显更为常见，表明 ART 与这两个危险因素呈显著负相关[χ2=10.24，r：-0.06，95%CI（-0.0974 至 -0.0221）和 χ2=47.25，r：-0.129，95%CI（-0.1656 至 -0.0913），p<0.01]。与自然妊娠相比，ART 诱导妊娠胎儿轻度心脏畸形的调整优势比（OR）为 1.37 倍[95%CI（1.072-1.769），p=0.01]。
尽管与自然妊娠相比，ART 诱导妊娠胎儿轻度心脏畸形的可能性高 1.37 倍，但 ART 并未增加重大心脏畸形的风险。
