Ko Seong Gyu, Kim Hwang-Phill, Jin Dong-Hoon, Bae Hyun-Su, Kim Sung Hoon, Park Chong-Hyeong, Lee Jung Weon
Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea.
Cancer Lett. 2005 Mar 18;220(1):11-9. doi: 10.1016/j.canlet.2004.06.026.
The molecular effects of Saussurea lappa extracts, a traditional medicine in Eastern Asia, on the fate of gastric carcinoma have not been understood. In this study, its cytostatic effects were examined using gastric AGS cancer cells. Its treatment resulted in apoptosis and G2-arrest in a dose- and time-dependent manner. The effects were attributed to the regulation of cyclins and pro-apoptotic molecules and suppression of anti-apoptotic molecules. Therefore, these results suggest that extracts of S. lappa root may be a candidate to deal with gastric cancers either by traditional herbal therapy or by combinational therapy with conventional chemotherapy.
东亚传统药物木香提取物对胃癌转归的分子作用尚未明确。本研究使用胃AGS癌细胞检测了其细胞生长抑制作用。其处理以剂量和时间依赖性方式导致细胞凋亡和G2期阻滞。这些作用归因于细胞周期蛋白和促凋亡分子的调控以及抗凋亡分子的抑制。因此，这些结果表明，木香根提取物可能是通过传统草药疗法或与传统化疗联合治疗来应对胃癌的候选药物。
