Gray Harry B, Winkler Jay R
Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA.
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3534-9. doi: 10.1073/pnas.0408029102. Epub 2005 Feb 28.
Recent investigations have shed much light on the nuclear and electronic factors that control the rates of long-range electron tunneling through molecules in aqueous and organic glasses as well as through bonds in donor-bridge-acceptor complexes. Couplings through covalent and hydrogen bonds are much stronger than those across van der Waals gaps, and these differences in coupling between bonded and nonbonded atoms account for the dependence of tunneling rates on the structure of the media between redox sites in Ru-modified proteins and protein-protein complexes.
最近的研究揭示了许多关于控制长程电子隧穿速率的核因素和电子因素，这些隧穿发生在水相和有机玻璃中的分子之间，以及供体-桥-受体复合物中的键之间。通过共价键和氢键的耦合比通过范德华间隙的耦合要强得多，键合原子与非键合原子之间耦合的这些差异解释了隧穿速率对钌修饰蛋白质和蛋白质-蛋白质复合物中氧化还原位点之间介质结构的依赖性。
