Konomi K, Imayama S, Nagae S, Terasaka R, Chijiiwa K, Yashima Y
Department of Surgery I, Kyushu University, Faculty of Medicine, Fukuoka, Japan.
J Surg Oncol. 1992 May;50(1):62-6. doi: 10.1002/jso.2930500117.
A 65-year-old woman underwent right modified radical mastectomy for a malignant lesion which had developed just below the right nipple. Two years after the operation, skin lesions composed of dark brown to black, pigmented, papular lesions developed in the precordia. A biopsy revealed this to be a cutaneous metastasis of the previous breast carcinoma. However numerous pigment blockade melanocytes were also found in the tumor nests, located in and/or beneath the epidermis. Although a black-colored breast carcinoma has been reported, the presence of pigment blockade melanocytes was not determined. Culture of the tumor nest recovered a population of melanocytes as well as the carcinoma cells. Boyden chamber analysis revealed the presence of a chemotactic factor for melanocytes in the culture medium. This seems to be the first documentation of melanocyte incorporation in breast carcinoma tissue.
一名65岁女性因右侧乳头下方出现的恶性病变接受了右改良根治性乳房切除术。术后两年，心前区出现了由深褐色至黑色的色素沉着丘疹性病变组成的皮肤病变。活检显示这是先前乳腺癌的皮肤转移。然而，在位于表皮内和/或表皮下的肿瘤巢中也发现了大量色素封闭性黑素细胞。虽然有报道称存在黑色乳腺癌，但未确定色素封闭性黑素细胞的存在。肿瘤巢培养物中分离出了一群黑素细胞以及癌细胞。Boyden小室分析显示培养基中存在黑素细胞趋化因子。这似乎是乳腺癌组织中黑素细胞掺入的首次记录。
